A P-Value for an Exact Two-Sided Test of Hardy-Weinberg Equilibrium

A two‐tailed P‐value is proposed for testing two‐sided departures from Hardy‐Weinberg equilibrium at a diallelic locus. The calculation of P uses the exact conditional distribution of the test statistic P, the observed number of heterozygotes in the sample. The proposed P‐value is always two‐tailed,...

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Bibliographic Details
Published in:Biometrical journal 1999-07, Vol.41 (4), p.499-505
Main Author: Meulepas, E.
Format: Article
Language:English
Subjects:
Applications
Applied sciences
Biology, psychology, social sciences
Computer science
control theory
systems
Computer systems performance. Reliability
Continuity correction
Distribution theory
Exact sciences and technology
Hardy-Weinberg equilibrium
Mathematics
Multivariate analysis
P-values
Probability and statistics
Sciences and techniques of general use
Software
Statistics
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Description
Summary:A two‐tailed P‐value is proposed for testing two‐sided departures from Hardy‐Weinberg equilibrium at a diallelic locus. The calculation of P uses the exact conditional distribution of the test statistic P, the observed number of heterozygotes in the sample. The proposed P‐value is always two‐tailed, unlike other P‐values proposed in the literature.
ISSN:0323-3847
1521-4036
DOI:10.1002/(SICI)1521-4036(199907)41:4<499::AID-BIMJ499>3.0.CO;2-B