Detection of subthreshold atrophy in crossed cerebellar degeneration via two-compartment mathematical modeling of cell density in DWI: A proof of concept study

Crossed cerebellar diaschisis (CCD) refers to transneuronal degeneration of the corticopontocerebellar pathway, resulting in atrophy of cerebellum contralateral to supratentorial pathology. CCD is traditionally diagnosed on nuclear medicine studies. Our aim is to apply a biexponential diffusion mode...

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Bibliographic Details
Published in:Medical hypotheses 2018-11, Vol.120, p.96-100
Main Authors: Kohannim, Omid, Huang, Jimmy C., Hathout, Gasser M.
Format: Article
Language:English
Subjects:
Adult
Atrophy
Brain Ischemia - pathology
Brain Mapping
Cerebellar Diseases - pathology
Cerebellum - pathology
Cerebrovascular Circulation
Crossed Cerebellar Diaschisis
Diffusion
Diffusion weighted MRI
Humans
Magnetic resonance imaging
Middle Cerebral Artery - pathology
Models, Theoretical
Neurodegenerative Diseases - pathology
Neurons - pathology
Proof of Concept Study
Stroke
Stroke - pathology
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Summary:Crossed cerebellar diaschisis (CCD) refers to transneuronal degeneration of the corticopontocerebellar pathway, resulting in atrophy of cerebellum contralateral to supratentorial pathology. CCD is traditionally diagnosed on nuclear medicine studies. Our aim is to apply a biexponential diffusion model, composed of intracellular and extracellular compartments, to the detection of subthreshold CCD on DWI, with the calculated fraction of the intracellular compartment as a proposed measure of cell density. At a voxel-by-voxel basis, we solve for intracellular and extracellular coefficients in each side of the cerebellum and compare the distribution of coefficients between each hemisphere. We demonstrate, in all six CCD cases, a significantly lower contribution of the intracellular compartment to the cerebellar hemisphere contralateral to supratentorial pathology (p 
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2018.08.025