In vitro antifungal combination effects of micafungin with fluconazole, voriconazole, amphotericin B, and flucytosine against clinical isolates of Candida species

Abstract Micafungin (MCFG) is an echinocandin antifungal agent that exhibits potent activity against most species of Candida and Aspergillus . We investigated the in vitro antifungal combination effects of MCFG with four other antifungal agents — fluconazole (FLCZ), voriconazole (VRCZ), amphotericin...

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Bibliographic Details
Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2009-02, Vol.15 (1), p.1-5
Main Authors: Nishi, Isao, Sunada, Atsuko, Toyokawa, Masahiro, Asari, Seishi, Iwatani, Yoshinori
Format: Article
Language:English
Subjects:
Amphotericin B
Amphotericin B - pharmacology
Antifungal Agents - pharmacology
Aspergillus
Candida
Candida - drug effects
Candida glabrata
Candidiasis - microbiology
Combination effect
Drug Synergism
Echinocandins - pharmacology
Fluconazole
Fluconazole - pharmacology
Flucytosine - pharmacology
Hematology, Oncology and Palliative Medicine
Humans
Infectious Diseases
Lipopeptides - pharmacology
Medical Microbiology
Medicine & Public Health
Micafungin
Original Article
Pyrimidines - pharmacology
Triazoles - pharmacology
Virology
Voriconazole
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Summary:Abstract Micafungin (MCFG) is an echinocandin antifungal agent that exhibits potent activity against most species of Candida and Aspergillus . We investigated the in vitro antifungal combination effects of MCFG with four other antifungal agents — fluconazole (FLCZ), voriconazole (VRCZ), amphotericin B, and flucytosine — against clinical isolates of 54 Candida spp. by checkerboard analysis. The synergistic antifungal effects of MCFG-FLCZ and MCFG-VRCZ were 11% and 15%, respectively, and the latter displayed a synergistic activity of 63% against Candida glabrata . Antagonism was not observed in any of the combinations tested.
ISSN:1341-321X
1437-7780
DOI:10.1007/s10156-008-0653-9