Neurotoxicity of 1-Methoxycycloheptatriene - A Purkinje Cell Toxicant

The toxicity of 1-methoxycycloheptatriene (1-MCHT), a sensory irritant, has been investigated in beagles. It was found to produce gross inco-ordination of the limbs at intravenous doses greater than 10 mg kg-1. The main histological abnormalities were in the cerebellum and consisted of Purkinje cell...

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Bibliographic Details
Published in:Human & experimental toxicology 1991-03, Vol.10 (2), p.93-101
Main Authors: Marrs, T.C., Allen, Ingrid V., Colgrave, H.F., McConnell, R.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Chemical Analysis
Brain - drug effects
Brain - pathology
Chemical and industrial products toxicology. Toxic occupational diseases
Cycloheptanes - toxicity
Dogs
Dose-Response Relationship, Drug
Female
Hematologic Tests
Male
Medical sciences
Nervous System Diseases - chemically induced
Purkinje Cells - drug effects
Purkinje Cells - pathology
Toxicology
Various organic compounds
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Summary:The toxicity of 1-methoxycycloheptatriene (1-MCHT), a sensory irritant, has been investigated in beagles. It was found to produce gross inco-ordination of the limbs at intravenous doses greater than 10 mg kg-1. The main histological abnormalities were in the cerebellum and consisted of Purkinje cell death and subsequent reactive gliosis. A few necrotic neurons were seen in the diencephalon, pons and medulla. Haematological abnormalities, e.g. leucocytosis with relative lymphopenia, were seen, while biochemical changes included hyperglycaemia and a rise in plasma aminotransferases. The no-effect dose for the histological and biochemical changes was the same. These abnormalities are compared with cerebellar changes observed in acrylamide and other toxic states.
ISSN:0960-3271
1477-0903
DOI:10.1177/096032719101000201