Tumor Necrosis Factor Polymorphisms and Alcoholic Liver Disease: A HuGE Review and Meta-Analysis

The association between alcoholic liver disease (ALD) and tumor necrosis factor-α gene (TNFA) polymorphisms has been analyzed in several studies, but results have been conflicting. The main purpose of this study was to integrate previous findings and explore whether these polymorphisms are associate...

Full description

Saved in:
Bibliographic Details
Published in:American journal of epidemiology 2009-10, Vol.170 (8), p.948-956
Main Authors: Marcos, Miguel, Gómez-Munuera, Mercedes, Pastor, Isabel, González-Sarmiento, Rogelio, Laso, Francisco-Javier
Format: Article
Language:English
Subjects:
alcoholic
Alcoholism
Alcoholism and acute alcohol poisoning
Analysis. Health state
Biological and medical sciences
Epidemiology
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Genetic Predisposition to Disease
genetics
genome
Genomics
human
Humans
Liver cirrhosis
Liver Cirrhosis, Alcoholic - genetics
Liver diseases
Liver Diseases, Alcoholic - genetics
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Meta-analysis
Miscellaneous
Other diseases. Semiology
Polymorphism
Polymorphism, Genetic
Public health. Hygiene
Public health. Hygiene-occupational medicine
review
Toxicology
tumor necrosis factor-alpha
Tumor Necrosis Factor-alpha - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The association between alcoholic liver disease (ALD) and tumor necrosis factor-α gene (TNFA) polymorphisms has been analyzed in several studies, but results have been conflicting. The main purpose of this study was to integrate previous findings and explore whether these polymorphisms are associated with susceptibility to ALD. The authors surveyed studies on the relation between TNFA gene polymorphisms and ALD by means of an electronic database search. A meta-analysis was conducted in a random-effects model. The association between ALD and the −238G>A or −308G>A polymorphism of the TNFA gene has been analyzed in 11 studies. Concerning the −238G>A polymorphism, the authors found a significant association between possession of the A allele and risk of alcoholic liver cirrhosis (odds ratio = 1.47, 95% confidence interval: 1.05, 2.07). Meta-analysis of the relation between the −308G>A polymorphism and ALD did not show any significant association. Given the limited number of studies and the potential biases, more data are needed to confirm the association described for the −238A allele.
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kwp236