DNA methylation during depleted uranium-induced leukemia

The radioactive heavy metal depleted uranium (DU) is used in kinetic-energy penetrators in military applications. The objective of this study was to determine involvement of DNA methylation in DU-induced leukemia. Methylation was measured by direct analysis of 5-methylcytosine content of spleen DNA...

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Bibliographic Details
Published in:Biochimie 2009-10, Vol.91 (10), p.1328-1330
Main Authors: Miller, Alexandra C., Stewart, Michael, Rivas, Rafael
Format: Article
Language:English
Subjects:
Animals
Blotting, Northern
Depleted uranium
DNA methylation
DNA Methylation - drug effects
Epigenetics
Gene activation
Leukemia
Leukemia - chemically induced
Leukemia - genetics
Male
Mice
Uranium - toxicity
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Summary:The radioactive heavy metal depleted uranium (DU) is used in kinetic-energy penetrators in military applications. The objective of this study was to determine involvement of DNA methylation in DU-induced leukemia. Methylation was measured by direct analysis of 5-methylcytosine content of spleen DNA in DU leukemic mice. Spleen hypomethylation occurred during DU-induced leukemogenesis (chronic internal DU exposure). Aberrant gene transcription was also detected. Epigenetic mechanisms are implicated in DU-induced leukemia. These data are evidence of aberrant DNA hypomethylation being associated with DU leukemogenesis.
ISSN:0300-9084
1638-6183
DOI:10.1016/j.biochi.2009.03.010