Chronic Low-Dose Exposure of Sodium Nitrite in VM-Strain Mice: Central Nervous System Changes

1 There is suggestive evidence that nitrite may be a causative factor in cerebral glioma. 2 To test this hypothesis we selected the VM mouse strain, known for its susceptibility to spontaneous glioma formation, and exposed 300 animals to 0.2% sodium nitrite in their drinking water. One hundred of th...

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Bibliographic Details
Published in:Human & experimental toxicology 1992-07, Vol.11 (4), p.279-281
Main Authors: Hawkes, C.H., Cavanagh, J.B., Darling, J.L., Watkins, B.A., Thomas, D.G.T.
Format: Article
Language:English
Subjects:
Administration, Oral
Analysis of Variance
Animals
Biological and medical sciences
Central Nervous System Neoplasms - chemically induced
Chemical and industrial products toxicology. Toxic occupational diseases
Female
Glioma - chemically induced
Male
Medical sciences
Metals and various inorganic compounds
Mice
Sodium Nitrite - administration & dosage
Sodium Nitrite - toxicity
Toxicology
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Summary:1 There is suggestive evidence that nitrite may be a causative factor in cerebral glioma. 2 To test this hypothesis we selected the VM mouse strain, known for its susceptibility to spontaneous glioma formation, and exposed 300 animals to 0.2% sodium nitrite in their drinking water. One hundred of this group were exposed both in utero and throughout their adult lives. The remaining 200 animals received nitrite from the time of weaning. A further 200 mice were used as controls and received distilled water. 3 All animals were maintained until their natural death and were then subjected to autopsy and routine histological examination. 4 There was no excess of nervous system tumours in the experimental groups.
ISSN:0960-3271
1477-0903
DOI:10.1177/096032719201100408