Reference values for young normal Sprague-Dawley rats: weight gain, hematology and clinical chemistry

1 Arterial blood from 63 male (315 - 500 g) and 60 female (210 - 290 g) healthy Sprague-Dawley rats was ana lyzed for 16 hematological and 22 clinical chemistry parameters. 2 Nine of these parameters were associated with growth and developmental changes in males between 38 - 78 days and females 49 -...

Full description

Saved in:
Bibliographic Details
Published in:Human & experimental toxicology 1996-08, Vol.15 (8), p.612-616
Main Authors: Lillie, Len E, Temple, Norman J, Florence, L. Zack
Format: Article
Language:English
Subjects:
Age Factors
Animals
Biological and medical sciences
Body Temperature
Body Weight
Female
General aspects. Methods
Hematologic Tests
Male
Medical sciences
Rats
Rats, Sprague-Dawley - blood
Rats, Sprague-Dawley - physiology
Reference Values
Sex Factors
Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c495t-37f40e20ceb31e71c2b1fc65eef3a79b4df73c8c2e04007c63f3e6540dabe15e3
cites cdi_FETCH-LOGICAL-c495t-37f40e20ceb31e71c2b1fc65eef3a79b4df73c8c2e04007c63f3e6540dabe15e3
container_end_page 616
container_issue 8
container_start_page 612
container_title Human & experimental toxicology
container_volume 15
creator Lillie, Len E
Temple, Norman J
Florence, L. Zack
description 1 Arterial blood from 63 male (315 - 500 g) and 60 female (210 - 290 g) healthy Sprague-Dawley rats was ana lyzed for 16 hematological and 22 clinical chemistry parameters. 2 Nine of these parameters were associated with growth and developmental changes in males between 38 - 78 days and females 49 - 89 days of age. 3 Weight gain in both sexes followed patterns consistent with other studies using this strain, but interexperi mental variation was as much as ± 22%. 4 Rectal temperatures of females averaged 37.28°C, being statistically greater (P < 0.05) than the average male at 36.99°C. 5 The data provide reference values for use in toxicolo gical and other investigations.
doi_str_mv 10.1177/096032719601500802
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_21092986</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_096032719601500802</sage_id><sourcerecordid>15668281</sourcerecordid><originalsourceid>FETCH-LOGICAL-c495t-37f40e20ceb31e71c2b1fc65eef3a79b4df73c8c2e04007c63f3e6540dabe15e3</originalsourceid><addsrcrecordid>eNqFkc1r3DAQxUVp2G62_QcKBR1KTnEykizLzq3kGwKBfpyNrB15vXiljWQ3-L-Pll1yCSSnObzfm2HeI-Q7gzPGlDqHqgDBFUuDSYAS-CcyZ7lSGVQgPpP5Dsh2xBdyHOMaAIpKshmZlWUhQIo5wd9oMaAzSP_rfsRIrQ908qNrqfNho3v6Zxt0O2J2pZ97nGjQQ7ygz9i1q4G2unOndIUbPfjetxPVbklN37nOJKdJQheHMH0lR1b3Eb8d5oL8u7n-e3mXPTze3l_-eshMXskhE8rmgBwMNoKhYoY3zJpCIlqhVdXkS6uEKQ1HyAGUKYQVWMgclrpBJlEsyMl-7zb4p_TMUKf7BvteO_RjrDmDilfp949AJoui5CVLIN-DJvgYA9p6G7qNDlPNoN6VUL8tIZl-HLaPzQaXr5ZD6kn_edB1TDnZoJ3p4ismOEheyoSd77GoW6zXfgwuhffe4RdOQ5y5</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15668281</pqid></control><display><type>article</type><title>Reference values for young normal Sprague-Dawley rats: weight gain, hematology and clinical chemistry</title><source>SAGE Deep Backfile 2012</source><creator>Lillie, Len E ; Temple, Norman J ; Florence, L. Zack</creator><creatorcontrib>Lillie, Len E ; Temple, Norman J ; Florence, L. Zack</creatorcontrib><description>1 Arterial blood from 63 male (315 - 500 g) and 60 female (210 - 290 g) healthy Sprague-Dawley rats was ana lyzed for 16 hematological and 22 clinical chemistry parameters. 2 Nine of these parameters were associated with growth and developmental changes in males between 38 - 78 days and females 49 - 89 days of age. 3 Weight gain in both sexes followed patterns consistent with other studies using this strain, but interexperi mental variation was as much as ± 22%. 4 Rectal temperatures of females averaged 37.28°C, being statistically greater (P &lt; 0.05) than the average male at 36.99°C. 5 The data provide reference values for use in toxicolo gical and other investigations.</description><identifier>ISSN: 0960-3271</identifier><identifier>ISSN: 0144-5952</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/096032719601500802</identifier><identifier>PMID: 8863053</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Age Factors ; Animals ; Biological and medical sciences ; Body Temperature ; Body Weight ; Female ; General aspects. Methods ; Hematologic Tests ; Male ; Medical sciences ; Rats ; Rats, Sprague-Dawley - blood ; Rats, Sprague-Dawley - physiology ; Reference Values ; Sex Factors ; Toxicology</subject><ispartof>Human &amp; experimental toxicology, 1996-08, Vol.15 (8), p.612-616</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-37f40e20ceb31e71c2b1fc65eef3a79b4df73c8c2e04007c63f3e6540dabe15e3</citedby><cites>FETCH-LOGICAL-c495t-37f40e20ceb31e71c2b1fc65eef3a79b4df73c8c2e04007c63f3e6540dabe15e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/096032719601500802$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/096032719601500802$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,21845,23930,23931,25140,27924,27925,45082,45470</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=3205285$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8863053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lillie, Len E</creatorcontrib><creatorcontrib>Temple, Norman J</creatorcontrib><creatorcontrib>Florence, L. Zack</creatorcontrib><title>Reference values for young normal Sprague-Dawley rats: weight gain, hematology and clinical chemistry</title><title>Human &amp; experimental toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>1 Arterial blood from 63 male (315 - 500 g) and 60 female (210 - 290 g) healthy Sprague-Dawley rats was ana lyzed for 16 hematological and 22 clinical chemistry parameters. 2 Nine of these parameters were associated with growth and developmental changes in males between 38 - 78 days and females 49 - 89 days of age. 3 Weight gain in both sexes followed patterns consistent with other studies using this strain, but interexperi mental variation was as much as ± 22%. 4 Rectal temperatures of females averaged 37.28°C, being statistically greater (P &lt; 0.05) than the average male at 36.99°C. 5 The data provide reference values for use in toxicolo gical and other investigations.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Temperature</subject><subject>Body Weight</subject><subject>Female</subject><subject>General aspects. Methods</subject><subject>Hematologic Tests</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley - blood</subject><subject>Rats, Sprague-Dawley - physiology</subject><subject>Reference Values</subject><subject>Sex Factors</subject><subject>Toxicology</subject><issn>0960-3271</issn><issn>0144-5952</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNqFkc1r3DAQxUVp2G62_QcKBR1KTnEykizLzq3kGwKBfpyNrB15vXiljWQ3-L-Pll1yCSSnObzfm2HeI-Q7gzPGlDqHqgDBFUuDSYAS-CcyZ7lSGVQgPpP5Dsh2xBdyHOMaAIpKshmZlWUhQIo5wd9oMaAzSP_rfsRIrQ908qNrqfNho3v6Zxt0O2J2pZ97nGjQQ7ygz9i1q4G2unOndIUbPfjetxPVbklN37nOJKdJQheHMH0lR1b3Eb8d5oL8u7n-e3mXPTze3l_-eshMXskhE8rmgBwMNoKhYoY3zJpCIlqhVdXkS6uEKQ1HyAGUKYQVWMgclrpBJlEsyMl-7zb4p_TMUKf7BvteO_RjrDmDilfp949AJoui5CVLIN-DJvgYA9p6G7qNDlPNoN6VUL8tIZl-HLaPzQaXr5ZD6kn_edB1TDnZoJ3p4ismOEheyoSd77GoW6zXfgwuhffe4RdOQ5y5</recordid><startdate>19960801</startdate><enddate>19960801</enddate><creator>Lillie, Len E</creator><creator>Temple, Norman J</creator><creator>Florence, L. Zack</creator><general>SAGE Publications</general><general>Arnold</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19960801</creationdate><title>Reference values for young normal Sprague-Dawley rats: weight gain, hematology and clinical chemistry</title><author>Lillie, Len E ; Temple, Norman J ; Florence, L. Zack</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-37f40e20ceb31e71c2b1fc65eef3a79b4df73c8c2e04007c63f3e6540dabe15e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Temperature</topic><topic>Body Weight</topic><topic>Female</topic><topic>General aspects. Methods</topic><topic>Hematologic Tests</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley - blood</topic><topic>Rats, Sprague-Dawley - physiology</topic><topic>Reference Values</topic><topic>Sex Factors</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lillie, Len E</creatorcontrib><creatorcontrib>Temple, Norman J</creatorcontrib><creatorcontrib>Florence, L. Zack</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Human &amp; experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lillie, Len E</au><au>Temple, Norman J</au><au>Florence, L. Zack</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reference values for young normal Sprague-Dawley rats: weight gain, hematology and clinical chemistry</atitle><jtitle>Human &amp; experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>1996-08-01</date><risdate>1996</risdate><volume>15</volume><issue>8</issue><spage>612</spage><epage>616</epage><pages>612-616</pages><issn>0960-3271</issn><issn>0144-5952</issn><eissn>1477-0903</eissn><abstract>1 Arterial blood from 63 male (315 - 500 g) and 60 female (210 - 290 g) healthy Sprague-Dawley rats was ana lyzed for 16 hematological and 22 clinical chemistry parameters. 2 Nine of these parameters were associated with growth and developmental changes in males between 38 - 78 days and females 49 - 89 days of age. 3 Weight gain in both sexes followed patterns consistent with other studies using this strain, but interexperi mental variation was as much as ± 22%. 4 Rectal temperatures of females averaged 37.28°C, being statistically greater (P &lt; 0.05) than the average male at 36.99°C. 5 The data provide reference values for use in toxicolo gical and other investigations.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>8863053</pmid><doi>10.1177/096032719601500802</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0960-3271
ispartof Human & experimental toxicology, 1996-08, Vol.15 (8), p.612-616
issn 0960-3271
0144-5952
1477-0903
language eng
recordid cdi_proquest_miscellaneous_21092986
source SAGE Deep Backfile 2012
subjects Age Factors
Animals
Biological and medical sciences
Body Temperature
Body Weight
Female
General aspects. Methods
Hematologic Tests
Male
Medical sciences
Rats
Rats, Sprague-Dawley - blood
Rats, Sprague-Dawley - physiology
Reference Values
Sex Factors
Toxicology
title Reference values for young normal Sprague-Dawley rats: weight gain, hematology and clinical chemistry
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T18%3A33%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reference%20values%20for%20young%20normal%20Sprague-Dawley%20rats:%20weight%20gain,%20hematology%20and%20clinical%20chemistry&rft.jtitle=Human%20&%20experimental%20toxicology&rft.au=Lillie,%20Len%20E&rft.date=1996-08-01&rft.volume=15&rft.issue=8&rft.spage=612&rft.epage=616&rft.pages=612-616&rft.issn=0960-3271&rft.eissn=1477-0903&rft_id=info:doi/10.1177/096032719601500802&rft_dat=%3Cproquest_cross%3E15668281%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c495t-37f40e20ceb31e71c2b1fc65eef3a79b4df73c8c2e04007c63f3e6540dabe15e3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=15668281&rft_id=info:pmid/8863053&rft_sage_id=10.1177_096032719601500802&rfr_iscdi=true