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Intranasal immunization of guinea pig with trivalent influenza antigen adjuvanted by Cyclamen europaeum tubers extract
Cyclamen europaeum tubers extract (CTE) with concentration commonly used for human rhinosinusitis treatment was tested as mucosal adjuvant in experimental intranasal immunization of guinea pigs with concentrated commercially available influenza trivalent vaccine and subsequent infection with influen...
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| Published in: | Archives of virology 2019-01, Vol.164 (1), p.243-247 |
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| cites | cdi_FETCH-LOGICAL-c372t-28a0b73113b5c3ac45dd3d7d49816f20565aae10c39f6a036a7b12c7de89bccc3 |
| container_end_page | 247 |
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| container_title | Archives of virology |
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| creator | Evseenko, Vasily A. Kolosova, Natalia P. Gudymo, Anderi S. Maltsev, Semion V. Bulanovich, Julia A. Goncharova, Nataliya I. Danilchenko, Natalia V. Marchenko, Vasiliy Y. Susloparov, Ivan M. Ryzhikov, Alexander B. |
| description | Cyclamen europaeum
tubers extract (CTE) with concentration commonly used for human rhinosinusitis treatment was tested as mucosal adjuvant in experimental intranasal immunization of guinea pigs with concentrated commercially available influenza trivalent vaccine and subsequent infection with influenza strain A/California/04/2009 H1N1pdm. Dual intranasal immunization with vaccine compound consisting of 7.5 µg of each hemagglutinin and 500 µg of CTE in 50 µl induced reciprocal GMT on day 21 after immunization 40 (5-640) against H1N1pdm; 43.20 (5-1280) against H3N2; 10.80 (5-80) against influenza B. Animals with HI titers 1/80 against cell-derived antigen were completely protected against challenge with A/California/04/2009 H1N1pdm09. |
| doi_str_mv | 10.1007/s00705-018-4023-3 |
| format | article |
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tubers extract (CTE) with concentration commonly used for human rhinosinusitis treatment was tested as mucosal adjuvant in experimental intranasal immunization of guinea pigs with concentrated commercially available influenza trivalent vaccine and subsequent infection with influenza strain A/California/04/2009 H1N1pdm. Dual intranasal immunization with vaccine compound consisting of 7.5 µg of each hemagglutinin and 500 µg of CTE in 50 µl induced reciprocal GMT on day 21 after immunization 40 (5-640) against H1N1pdm; 43.20 (5-1280) against H3N2; 10.80 (5-80) against influenza B. Animals with HI titers 1/80 against cell-derived antigen were completely protected against challenge with A/California/04/2009 H1N1pdm09.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s00705-018-4023-3</identifier><identifier>PMID: 30225522</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Adjuvants, Immunologic ; Administration, Intranasal ; Animals ; Antigens ; Biomedical and Life Sciences ; Biomedicine ; Brief Report ; Cyclamen ; Cyclamen - chemistry ; Guinea Pigs ; Hemagglutinins ; Immunization ; Infectious Diseases ; Influenza ; Influenza B ; Influenza Vaccines - immunology ; Medical Microbiology ; Mucosa ; Orthomyxoviridae Infections - prevention & control ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Rhinosinusitis ; Tubers ; Vaccines ; Virology</subject><ispartof>Archives of virology, 2019-01, Vol.164 (1), p.243-247</ispartof><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2018</rights><rights>Archives of Virology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-28a0b73113b5c3ac45dd3d7d49816f20565aae10c39f6a036a7b12c7de89bccc3</citedby><cites>FETCH-LOGICAL-c372t-28a0b73113b5c3ac45dd3d7d49816f20565aae10c39f6a036a7b12c7de89bccc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30225522$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Evseenko, Vasily A.</creatorcontrib><creatorcontrib>Kolosova, Natalia P.</creatorcontrib><creatorcontrib>Gudymo, Anderi S.</creatorcontrib><creatorcontrib>Maltsev, Semion V.</creatorcontrib><creatorcontrib>Bulanovich, Julia A.</creatorcontrib><creatorcontrib>Goncharova, Nataliya I.</creatorcontrib><creatorcontrib>Danilchenko, Natalia V.</creatorcontrib><creatorcontrib>Marchenko, Vasiliy Y.</creatorcontrib><creatorcontrib>Susloparov, Ivan M.</creatorcontrib><creatorcontrib>Ryzhikov, Alexander B.</creatorcontrib><title>Intranasal immunization of guinea pig with trivalent influenza antigen adjuvanted by Cyclamen europaeum tubers extract</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><addtitle>Arch Virol</addtitle><description>Cyclamen europaeum
tubers extract (CTE) with concentration commonly used for human rhinosinusitis treatment was tested as mucosal adjuvant in experimental intranasal immunization of guinea pigs with concentrated commercially available influenza trivalent vaccine and subsequent infection with influenza strain A/California/04/2009 H1N1pdm. Dual intranasal immunization with vaccine compound consisting of 7.5 µg of each hemagglutinin and 500 µg of CTE in 50 µl induced reciprocal GMT on day 21 after immunization 40 (5-640) against H1N1pdm; 43.20 (5-1280) against H3N2; 10.80 (5-80) against influenza B. Animals with HI titers 1/80 against cell-derived antigen were completely protected against challenge with A/California/04/2009 H1N1pdm09.</description><subject>Adjuvants, Immunologic</subject><subject>Administration, Intranasal</subject><subject>Animals</subject><subject>Antigens</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brief Report</subject><subject>Cyclamen</subject><subject>Cyclamen - chemistry</subject><subject>Guinea Pigs</subject><subject>Hemagglutinins</subject><subject>Immunization</subject><subject>Infectious Diseases</subject><subject>Influenza</subject><subject>Influenza B</subject><subject>Influenza Vaccines - immunology</subject><subject>Medical Microbiology</subject><subject>Mucosa</subject><subject>Orthomyxoviridae Infections - prevention & control</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Rhinosinusitis</subject><subject>Tubers</subject><subject>Vaccines</subject><subject>Virology</subject><issn>0304-8608</issn><issn>1432-8798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kU2LFDEQhoMo7rj6A7xIwIuX1krSH-mjDKsuLHjRc6hOV48ZutNjPkZnf70ZZlUQvCSk8tRbBQ9jLwW8FQDdu1gOaCoQuqpBqko9YhtRK1nprteP2QYU1JVuQV-xZzHuAUpBNU_ZlQIpm0bKDTve-hTQY8SZu2XJ3t1jcqvn68R32XlCfnA7_sOlbzwFd8SZfOLOT3Mmf48cfXI78hzHfT6WB418OPHtyc64lDLlsB6Q8sJTHihETj_LOJuesycTzpFePNzX7OuHmy_bT9Xd54-32_d3lVWdTJXUCEOnhFBDYxXauhlHNXZj3WvRThKatkEkAVb1U4ugWuwGIW03ku4Ha626Zm8uuYewfs8Uk1lctDTP6GnN0UgBvZJdrdqCvv4H3a85-LLdmdIgtW6bQokLZcMaY6DJHIJbMJyMAHOWYi5STJFizlKMKj2vHpLzsND4p-O3hQLICxDLl99R-Dv6_6m_AAkYmRs</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Evseenko, Vasily A.</creator><creator>Kolosova, Natalia P.</creator><creator>Gudymo, Anderi S.</creator><creator>Maltsev, Semion V.</creator><creator>Bulanovich, Julia A.</creator><creator>Goncharova, Nataliya I.</creator><creator>Danilchenko, Natalia V.</creator><creator>Marchenko, Vasiliy Y.</creator><creator>Susloparov, Ivan M.</creator><creator>Ryzhikov, Alexander B.</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20190101</creationdate><title>Intranasal immunization of guinea pig with trivalent influenza antigen adjuvanted by Cyclamen europaeum tubers extract</title><author>Evseenko, Vasily A. ; Kolosova, Natalia P. ; Gudymo, Anderi S. ; Maltsev, Semion V. ; Bulanovich, Julia A. ; Goncharova, Nataliya I. ; Danilchenko, Natalia V. ; Marchenko, Vasiliy Y. ; Susloparov, Ivan M. ; Ryzhikov, Alexander B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-28a0b73113b5c3ac45dd3d7d49816f20565aae10c39f6a036a7b12c7de89bccc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adjuvants, Immunologic</topic><topic>Administration, Intranasal</topic><topic>Animals</topic><topic>Antigens</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brief Report</topic><topic>Cyclamen</topic><topic>Cyclamen - 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Academic</collection><jtitle>Archives of virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Evseenko, Vasily A.</au><au>Kolosova, Natalia P.</au><au>Gudymo, Anderi S.</au><au>Maltsev, Semion V.</au><au>Bulanovich, Julia A.</au><au>Goncharova, Nataliya I.</au><au>Danilchenko, Natalia V.</au><au>Marchenko, Vasiliy Y.</au><au>Susloparov, Ivan M.</au><au>Ryzhikov, Alexander B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intranasal immunization of guinea pig with trivalent influenza antigen adjuvanted by Cyclamen europaeum tubers extract</atitle><jtitle>Archives of virology</jtitle><stitle>Arch Virol</stitle><addtitle>Arch Virol</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>164</volume><issue>1</issue><spage>243</spage><epage>247</epage><pages>243-247</pages><issn>0304-8608</issn><eissn>1432-8798</eissn><abstract>Cyclamen europaeum
tubers extract (CTE) with concentration commonly used for human rhinosinusitis treatment was tested as mucosal adjuvant in experimental intranasal immunization of guinea pigs with concentrated commercially available influenza trivalent vaccine and subsequent infection with influenza strain A/California/04/2009 H1N1pdm. Dual intranasal immunization with vaccine compound consisting of 7.5 µg of each hemagglutinin and 500 µg of CTE in 50 µl induced reciprocal GMT on day 21 after immunization 40 (5-640) against H1N1pdm; 43.20 (5-1280) against H3N2; 10.80 (5-80) against influenza B. Animals with HI titers 1/80 against cell-derived antigen were completely protected against challenge with A/California/04/2009 H1N1pdm09.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>30225522</pmid><doi>10.1007/s00705-018-4023-3</doi><tpages>5</tpages></addata></record> |
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| subjects | Adjuvants, Immunologic Administration, Intranasal Animals Antigens Biomedical and Life Sciences Biomedicine Brief Report Cyclamen Cyclamen - chemistry Guinea Pigs Hemagglutinins Immunization Infectious Diseases Influenza Influenza B Influenza Vaccines - immunology Medical Microbiology Mucosa Orthomyxoviridae Infections - prevention & control Plant Extracts - chemistry Plant Extracts - pharmacology Rhinosinusitis Tubers Vaccines Virology |
| title | Intranasal immunization of guinea pig with trivalent influenza antigen adjuvanted by Cyclamen europaeum tubers extract |
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