Analysis of the Association of TNF -238G>A Gene Polymorphism with the Risk of Rheumatoid Arthritis Development in Russian Population in the Republic of Karelia

We studied association of the TNF gene -238G>A polymorphism ( rs361525 ) with the risk of rheumatoid arthritis development in the Russian population living in the Republic of Karelia. The influence of rs361525 on the development of rheumatoid arthritis was revealed: genetic predisposition to this...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2018-09, Vol.165 (5), p.674-677
Main Authors: Malysheva, I. E., Topchieva, L. V., Balan, O. V., Marusenko, I. M., Barysheva, O. Yu, Kurbatova, I. V.
Format: Article
Language:English
Subjects:
Alleles
Arthritis, Rheumatoid - diagnosis
Arthritis, Rheumatoid - ethnology
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - pathology
Biomedical and Life Sciences
Biomedicine
Case-Control Studies
Cell Biology
Female
Gene Expression
Gene Frequency
Gene polymorphism
Genetic Predisposition to Disease
Health risk assessment
Humans
Internal Medicine
Laboratory Medicine
Male
Middle Aged
Pathology
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Rheumatoid arthritis
Risk Factors
Russia
Tumor Necrosis Factor-alpha - genetics
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Summary:We studied association of the TNF gene -238G>A polymorphism ( rs361525 ) with the risk of rheumatoid arthritis development in the Russian population living in the Republic of Karelia. The influence of rs361525 on the development of rheumatoid arthritis was revealed: genetic predisposition to this disease is associated with the presence of GG genotype. The effect of the genotype on the polymorphic locus of -238G>A on TNF mRNA content was revealed. Increased content of transcripts of this gene is associated with the presence of A allele.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-018-4239-y