Expression of microRNA Potentially Regulated by AhR and CAR in Malignant Tumors of the Endometrium

We studied microRNA whose expression can be regulated by carcinogenic compounds. Bioinformatic analysis has detected microRNA potentially regulated by xenosensor receptors AhR (miR-28, miR-30c, miR-30e, miR-139, and miR-153) and CAR (miR-29c, miR-31, miR-185, miR-625, and miR-652). Published data in...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2018-09, Vol.165 (5), p.688-691
Main Authors: Ushakov, D. S., Dorozhkova, A. S., Babayants, E. V., Ovchinnikov, V. Yu, Kushlinskii, D. N., Adamyan, L. V., Gulyaeva, L. F., Kushlinskii, N. E.
Format: Article
Language:English
Subjects:
Aged
Basic Helix-Loop-Helix Transcription Factors - genetics
Basic Helix-Loop-Helix Transcription Factors - metabolism
Binding Sites
Biomedical and Life Sciences
Biomedicine
Cancer
Carcinogenesis
Carcinogenesis - genetics
Carcinogenesis - metabolism
Carcinogenesis - pathology
Cell Biology
Computational Biology
Endometrial cancer
Endometrial Neoplasms - diagnosis
Endometrial Neoplasms - genetics
Endometrial Neoplasms - metabolism
Endometrial Neoplasms - pathology
Endometrium
Endometrium - metabolism
Endometrium - pathology
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Internal Medicine
Laboratory Medicine
Medical research
MicroRNA
MicroRNAs
MicroRNAs - classification
MicroRNAs - genetics
MicroRNAs - metabolism
Middle Aged
miRNA
Neoplasm Staging
Pathology
Receptors, Aryl Hydrocarbon - genetics
Receptors, Aryl Hydrocarbon - metabolism
Receptors, Cytoplasmic and Nuclear - genetics
Receptors, Cytoplasmic and Nuclear - metabolism
Response Elements
Tumors
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Summary:We studied microRNA whose expression can be regulated by carcinogenic compounds. Bioinformatic analysis has detected microRNA potentially regulated by xenosensor receptors AhR (miR-28, miR-30c, miR-30e, miR-139, and miR-153) and CAR (miR-29c, miR-31, miR-185, miR-625, and miR-652). Published data indicate that these microRNAs are oncosuppressors, except miR-31 that can act as an oncogene. The expression of these microRNAs in malignant tumors of the endometrium was studied. The expression of the majority of the studied microRNAs, except miR-652, was 2-3-fold below the normal, which confirms their oncosuppressor function and indicates their involvement in the endometrial carcinogenesis and hence, allows considering them as potential markers of the disease.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-018-4242-3