Evaluating the use of intra-articular injections as a treatment for painful hip osteoarthritis: a randomized, double-blind, multicenter, parallel-group study comparing a single 6-mL injection of hylan G-F 20 with saline

• Published in: Osteoarthritis and cartilage 2019-01, Vol.27 (1), p.59-70
• Main Authors: Brander, V., Skrepnik, N., Petrella, R.J., Jiang, G.-L., Accomando, B., Vardanyan, A.
• Format: Article
• Language: English
• Subjects: Acetaminophen - therapeutic use; Aged; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Double-Blind Method; Drug Therapy, Combination; Female; Hip osteoarthritis; Humans; Hyaluronic Acid - administration & dosage; Hyaluronic Acid - adverse effects; Hyaluronic Acid - analogs & derivatives; Hyaluronic Acid - therapeutic use; Hylan G-F 20; Injections, Intra-Articular; Intra-articular injections; Male; Middle Aged; Osteoarthritis; Osteoarthritis, Hip - complications; Osteoarthritis, Hip - drug therapy; Pain - etiology; Pain Measurement - methods; Saline Solution; Severity of Illness Index; Synvisc-one; Viscosupplements - administration & dosage; Viscosupplements - adverse effects; Viscosupplements - therapeutic use; Walking
• ISSN: 1063-4584; 1522-9653
• DOI: 10.1016/j.joca.2018.08.018

Hip osteoarthritis (OA) is difficult to treat. Steroid injections reduce pain with short duration. With widespread adoption of office-based, image-guided injections, hyaluronic acid is a potentially relevant therapy. In the largest clinical trial to-date, we compared safety/efficacy of a single, 6-mL image-guided injection of hylan G-F 20 to saline in painful hip OA. 357 patients were enrolled in a multicenter, double-blind, randomized saline placebo- controlled trial. Subjects were ≥35 years of age, with painful (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]-A1:5.0–8.0; numeric rating scale [NRS]: 0–10) mild-to-moderate hip OA (Kellgren–Lawrence grade II/III) and minimal contralateral hip pain (WOMAC-A1