Micromotors for drug delivery in vivo: The road ahead

Autonomously propelled/externally guided micromotors overcome current drug delivery challenges by providing (a) higher drug loading capacity, (b) localized delivery (less toxicity), (c) enhanced tissue penetration and (d) active maneuvering in vivo. These microscale drug delivery systems can exploit...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2019-01, Vol.138, p.41-55
Main Authors: Srivastava, Sarvesh Kumar, Clergeaud, Gael, Andresen, Thomas L., Boisen, Anja
Format: Article
Language:English
Subjects:
Animals
Body Fluids
Drug delivery in vivo
Drug Delivery Systems
External trigger actuation
Gastrointestinal Tract
GI tract
Humans
Light
Magnetic Fields
Micromotors
Microtechnology
Solid tumor
Treatment Outcome
Ultrasonic Waves
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Summary:Autonomously propelled/externally guided micromotors overcome current drug delivery challenges by providing (a) higher drug loading capacity, (b) localized delivery (less toxicity), (c) enhanced tissue penetration and (d) active maneuvering in vivo. These microscale drug delivery systems can exploit biological fluids, as well as exogenous stimuli, like light-NIR, ultrasound and magnetic fields (or a combination of these), towards propulsion/drug release. Ability of these wireless drug carriers towards localized targeting and controlled drug release, makes them a lucrative candidate for drug administration in complex microenvironments (like solid tumors or gastrointestinal tract). In this report, we discuss these microscale drug delivery systems for their therapeutic benefits under in vivo setting and provide a design-application rationale towards greater clinical significance. Also, a proof-of-concept depicting 'microbots-in-a-capsule' towards oral drug delivery has been discussed. [Display omitted]
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2018.09.005