Enhancing contrast to noise ratio of hippocampi affected with mesial temporal sclerosis: A case-control study in children undergoing epilepsy surgeries

• Published in: Clinical neurology and neurosurgery 2018-11, Vol.174, p.144-148
• Main Authors: Orlowski, Hilary L.P., Smyth, Matthew D., Parsons, Matthew S., Dahiya, Sonika, Sharifai, Nima, Hildebolt, Charles, Sharma, Aseem
• Format: Article
• Language: English
• Subjects: Accuracy; Algorithms; Biopsy; Children; Conflicts of interest; Contrast to noise ratio; Epilepsy; Hippocampus; Image processing; Magnetic resonance imaging; Medical imaging; Mesial temporal sclerosis; Neurology; NMR; Noise; Nuclear magnetic resonance; Patients; Pediatrics; Sclerosis; Sensitivity; Statistical analysis; Substantia grisea
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2018.09.005

•Post-processing increases CNR in diseased hippocampi when compared to baseline.•Post-processing increases diagnostic accuracy in detection of signal alteration.•Confidence in signal detection rating is increased in controls following processing. Detection of mesial temporal sclerosis (MTS) in children with epilepsy is important. We assessed whether an image-processing algorithm (Correlative Image Enhancement, CIE) could facilitate recognition of hippocampal signal abnormality in the presence of MTS by increasing contrast to noise ratio between affected hippocampus and normal gray matter. Patients and Methods: Baseline coronal FLAIR images from brain MRIs of 27 children with epilepsy who underwent hippocampal resection were processed using CIE. These included 19 hippocampi with biopsy proven MTS and 8 biopsy proven normal hippocampi resected in conjunction with hemispherotomy. We assessed the effect of processing on contrast to noise ratio (CNR) between hippocampus and normal insular gray matter, and on assessment of hippocampal signal abnormality by two masked neuroradiologists. Processing resulted in a significant increase in mean CNR (from 3.9 ± 5.3 to 25.3 ± 25.8; P 100%) increase from baseline seen in 15/19 (78.9%) cases. Baseline CNR of 1.7 ± 5.3 for normal hippocampi did not change significantly after processing (1.8 ± 5.3; P = 1.00). For one reader, baseline sensitivity (14/19; 73.6%) was unaffected but the specificity improved from 62.5% (5/8) to 100%. An increase in both sensitivity (from 73.6% to 78.9%) and specificity (from 62.5% to 75%) was seen for the second reader. By enhancing CNR for diseased hippocampi while leaving normal hippocampi relatively unaffected, CIE may improve the diagnostic accuracies of radiologists in detecting MTS-related signal alteration within the affected hippocampus.