IL‐4 dysregulates microRNAs involved in inflammation, angiogenesis and apoptosis in epidermal keratinocytes

• Published in: Microbiology and immunology 2018-11, Vol.62 (11), p.732-736
• Main Authors: Bao, Lei, Chau, Cecilia, Bao, Jeremy, Tsoukas, Maria M., Chan, Lawrence S.
• Format: Article
• Language: English
• Subjects: Angiogenesis; Angiogenesis Inducing Agents - immunology; Animals; Apoptosis; Apoptosis - immunology; Atopic dermatitis; Dermatitis; Dermatitis, Atopic - genetics; Dermatitis, Atopic - immunology; Dermatitis, Atopic - pathology; Down-Regulation; Eczema; Gene regulation; Humans; IL‐4; Inflammation; Inflammation - genetics; Inflammation - immunology; Interleukin-4 - genetics; Interleukin-4 - immunology; Keratinocytes; Keratinocytes - cytology; Keratinocytes - immunology; Lymphangiogenesis - genetics; Lymphangiogenesis - immunology; Mice; Mice, Transgenic; microRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - immunology; miRNA; Rodents; Transcription factors; Transgenic mice; Up-Regulation
• ISSN: 0385-5600; 1348-0421
• DOI: 10.1111/1348-0421.12650

ABSTRACT IL‐4 plays an important role in the pathogenesis of atopic dermatitis (AD) by dysregulating many key factors at the transcriptional level. In this study, a microRNA array technique and IL‐4 transgenic mice were used to demonstrate that IL‐4 dysregulates microRNAs involved in inflammation, angiogenesis, lymphangiogenesis and apoptosis. Of the 372 common microRNAs examined, 26 and one microRNAs were found to be up‐ and down‐regulated, respectively. MicroRNA‐101‐5p, −122‐5p, −142‐3p, −204‐5p, −335‐3p, −376a‐3p, −378a‐5p, −639 and −9‐5p are among the most significantly up‐regulated microRNAs. MicroRNA‐147a, the only one that was down‐ regulated in the present study, attenuates TLR‐induced inflammatory responses. These dysregulated microRNAs may provide post‐transcriptional regulation of key genes in AD.