Clinical significance of fucosylated GP73 in the differential diagnosis of hepatocellular carcinoma

Objective: To investigate the clinical value of fucosylated GP73 (Fuc-GP73) levels for differential diagnosis of hepatocellular carcinoma from other liver diseases. Methods: Serum specimens were collected from 50 patients with hepatocellular carcinoma, 60 patients with other digestive system disease...

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Bibliographic Details
Published in:The International journal of biological markers 2018-11, Vol.33 (4), p.439-446
Main Authors: Zhao, Yunsheng, Zhang, Lina, Huo, Lijing, Pei, Liu, Li, Qiuping, Li, Hongchen, Jin, Liang
Format: Article
Language:English
Subjects:
Adult
Affinity chromatography
Aged
Area Under Curve
Biomarkers
Biomarkers, Tumor - blood
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - pathology
Clinical significance
Diagnosis, Differential
Differential diagnosis
Digestive system diseases
Enzyme-linked immunosorbent assay
Female
Fucose - metabolism
Glycosylation
Hepatocellular carcinoma
Humans
Liver cancer
Liver diseases
Liver Neoplasms - blood
Liver Neoplasms - diagnosis
Liver Neoplasms - pathology
Lymph nodes
Male
Medical diagnosis
Membrane Proteins - blood
Membrane Proteins - chemistry
Metastases
Metastasis
Middle Aged
Protein Stability
Reproducibility of Results
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Summary:Objective: To investigate the clinical value of fucosylated GP73 (Fuc-GP73) levels for differential diagnosis of hepatocellular carcinoma from other liver diseases. Methods: Serum specimens were collected from 50 patients with hepatocellular carcinoma, 60 patients with other digestive system diseases (ODSD), and 40 normal controls. Lectin affinity chromatography column combining with the enzyme-linked immunosorbent assay (ELISA) using the ELISA index was utilized to measure the level of Fuc-GP73. By receiver operating characteristic (ROC) curve analysis its sensitivity and specificity were used to evaluate the diagnostic significance of Fuc-GP73 in hepatocellular carcinoma. Results: The median serum Fuc-GP73 level of hepatocellular carcinoma (20.4 μg/L) was much higher than that of ODSD patients (1.8 μg/L) and the normal controls group (0.3 μg/L), significantly (P 0.05); however, it was related to tumor, node, metastasis stage and lymph node metastasis (P
ISSN:1724-6008
0393-6155
1724-6008
DOI:10.1177/1724600818796646