Open Atrial Transcatheter Mitral Valve Replacement in Patients With Mitral Annular Calcification

• Published in: Journal of the American College of Cardiology 2018-09, Vol.72 (13), p.1437-1448
• Main Authors: Russell, Hyde M., Guerrero, Mayra E., Salinger, Michael H., Manzuk, Melissa A., Pursnani, Amit K., Wang, Dee, Nemeh, Hassan, Sakhuja, Rahul, Melnitchouk, Serguei, Pershad, Ashish, Fang, H. Kenith, Said, Sameh M., Kauten, James, Tang, Gilbert H.L., Aldea, Gabriel, Feldman, Ted E., Bapat, Vinnie N., George, Isaac M.
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Balloon Valvuloplasty; Calcinosis - surgery; Female; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation - methods; Humans; Male; mitral annular calcification; Mitral Valve - diagnostic imaging; Mitral Valve - surgery; Postoperative Care; Preoperative Care; surgery; Tomography, X-Ray Computed; valve replacement
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2018.07.033

Mitral valve replacement in the setting of severe mitral annular calcification remains a surgical challenge. Transcatheter mitral valve replacement (TMVR) using an aortic balloon-expandable transcatheter heart valve is emerging as a potential treatment option for high surgical risk patients. Transseptal, transapical, or transatrial access is not always feasible, so an understanding of alternative implantation techniques is important. The authors sought to present a step-by-step description of a contemporary transatrial TMVR technique using balloon-expandable aortic transcatheter heart valves. This procedure has evolved over time to address valve migration, left ventricular outflow tract obstruction, and paravalvular leak. The authors present a refined technique that has been associated with the most reproducible outcomes. A step-by-step description of the TMVR technique and outcomes of 8 patients treated using this technique are described. Baseline patient clinical and echocardiographic characteristics and 30-day post-TMVR outcomes are presented. Eight patients underwent transatrial TMVR at a single institution. Five had previous cardiac surgery. Mean STS score was 8%. Technical success by MVARC (Mitral Valve Academic Research Consortium) criteria was 100%. There was zero in-hospital and 30-day mortality. Procedural success by MVARC criteria at 30 days was 100%. Paravalvular leak immediately post-implant was none or trace in 6 and mild in 1. The technique described is reproducible and was associated with favorable outcomes in this early experience. It represents a useful technique for the treatment of mitral valve disease in the setting of severe annular calcification. A structured and defined implantation technique is critical to investigators as this field evolves. [Display omitted]