Progress in characterizing the linkage between Fusobacterium nucleatum and gastrointestinal cancer

Microbiome research is a rapidly advancing field in human cancers. Fusobacterium nucleatum is an oral bacterium, indigenous to the human oral cavity, that plays a role in periodontal disease. Recent studies have found that F. nucleatum can promote gastrointestinal tumor progression and affect the pr...

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Bibliographic Details
Published in:Journal of gastroenterology 2019-01, Vol.54 (1), p.33-41
Main Authors: Liu, Yang, Baba, Yoshifumi, Ishimoto, Takatsugu, Iwatsuki, Masaaki, Hiyoshi, Yukiharu, Miyamoto, Yuji, Yoshida, Naoya, Wu, Rong, Baba, Hideo
Format: Article
Language:English
Subjects:
Abdominal Surgery
Cancer
Colorectal cancer
Colorectal Surgery
Development and progression
Disease Progression
Drug Resistance, Neoplasm
Esophageal cancer
Fusobacterium Infections - complications
Fusobacterium nucleatum
Fusobacterium nucleatum - isolation & purification
Gastroenterology
Gastrointestinal cancer
Gastrointestinal Neoplasms - drug therapy
Gastrointestinal Neoplasms - microbiology
Gastrointestinal Neoplasms - pathology
Gram-negative bacteria
Hepatology
Humans
Medical colleges
Medicine
Medicine & Public Health
Microbiomes
Microbiota
Oncology, Experimental
Oral cavity
Periodontics
Prognosis
Review
Surgical Oncology
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Summary:Microbiome research is a rapidly advancing field in human cancers. Fusobacterium nucleatum is an oral bacterium, indigenous to the human oral cavity, that plays a role in periodontal disease. Recent studies have found that F. nucleatum can promote gastrointestinal tumor progression and affect the prognosis of the disease. In addition, F. nucleatum may contribute to the chemo-resistance of gastrointestinal cancers. This review summarizes recent progress in the pathogenesis of F. nucleatum and its impact on gastrointestinal cancer.
ISSN:0944-1174
1435-5922
DOI:10.1007/s00535-018-1512-9