Near-Infrared Laser-Driven in Situ Self-Assembly as a General Strategy for Deep Tumor Therapy

Nanotherapeutics have encountered some bottleneck problems in cancer therapy, such as poor penetration and inefficient accumulation in tumor site. We herein developed a novel strategy for deep tissue penetration in molecular level and near-infrared (NIR) laser guided in situ self-assembly to solve t...

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Bibliographic Details
Published in:Nano letters 2018-10, Vol.18 (10), p.6577-6584
Main Authors: Liu, Fu-Hua, Cong, Yong, Qi, Guo-Bin, Ji, Lei, Qiao, Zeng-Ying, Wang, Hao
Format: Article
Language:English
Subjects:
Cell Line, Tumor
Doxorubicin - administration & dosage
Doxorubicin - chemistry
Drug Delivery Systems
Gold - chemistry
Humans
Hyperthermia, Induced - methods
Infrared Rays
Lasers
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Neoplasms - drug therapy
Neoplasms - pathology
Polymers - chemistry
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Summary:Nanotherapeutics have encountered some bottleneck problems in cancer therapy, such as poor penetration and inefficient accumulation in tumor site. We herein developed a novel strategy for deep tissue penetration in molecular level and near-infrared (NIR) laser guided in situ self-assembly to solve these challenges. For the proof-of-concept study, we synthesized the polymer–peptide conjugates (PPCs) composed of (i) poly­(β-thioester) as thermoresponsive backbone, (ii) functional peptides (cytotoxic peptide and cell-penetrating peptide), and (iii) the NIR molecule with photothermal property. The PPCs in the molecular level with small size (
ISSN:1530-6984
1530-6992
DOI:10.1021/acs.nanolett.8b03174