Buccal micronucleus cytome biomarkers in Algerian couples with idiopathic infertility

•Buccal micronucleus cytomeassay was applied to idiopathic infertility.•Rise of DNA damage biomarkers (micronuclei, nuclear buds) in idiopathic infertility.•Biomarkers of cytokinesis-failure (binucleated cells) elevated in idiopathic infertility.•Cell death biomarkers increased in idiopathic inferti...

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Bibliographic Details
Published in:Mutation research. Genetic toxicology and environmental mutagenesis 2018-11, Vol.835, p.32-35
Main Authors: Laanani, Ismahane, Boutelis, Safia, Bennoune, Omar, Belaaloui, Ghania
Format: Article
Language:English
Subjects:
Adult
Algeria - epidemiology
Biomarkers
Biomarkers - analysis
Buccal micronucleus cytome
Cell Death
Cell Nucleus - genetics
Cytokinesis
DNA Damage
Female
Humans
Idiopathic infertility
Infertility - diagnosis
Infertility - epidemiology
Infertility - genetics
Male
Micronuclei
Micronucleus Tests - methods
Middle Aged
Mouth Mucosa - metabolism
Mouth Mucosa - pathology
Young Adult
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Summary:•Buccal micronucleus cytomeassay was applied to idiopathic infertility.•Rise of DNA damage biomarkers (micronuclei, nuclear buds) in idiopathic infertility.•Biomarkers of cytokinesis-failure (binucleated cells) elevated in idiopathic infertility.•Cell death biomarkers increased in idiopathic infertility. The buccal micronucleus cytome (BMCyt) assay is a useful and a minimally invasive cytogenetic method for measuring genomic damage. The aim of the present study is to evaluate the extent of chromosomal damage in couples with idiopathic infertility using a BMCyt. This study included 54 patients (27 couples) with idiopathic infertility and 30 fertile subjects (15 couples). When evaluated by individual (each subject from the couple is considered separately), the frequencies of micronucleated cells (MNC), total micronuclei (TMN), nuclear buds (NBUD), and binucleated cells (BN) were significantly higher in the infertile individuals than in the fertile ones (p = 0.009, p = 0.009, p = 0.003 and p 
ISSN:1383-5718
1879-3592
DOI:10.1016/j.mrgentox.2018.08.010