TEKT4 Promotes Papillary Thyroid Cancer Cell Proliferation, Colony Formation, and Metastasis through Activating PI3K/Akt Pathway

Thyroid carcinoma is the most common malignancy of the endocrine system worldwide, but its molecular mechanisms remain unclear. Some diseases are associated with TEKT4 gene. However, its role in thyroid carcinoma has yet to be fully examined. This study was designed to investigate the function of TE...

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Bibliographic Details
Published in:Endocrine pathology 2018-12, Vol.29 (4), p.310-316
Main Authors: Zheng, Zhouci, Zhou, Xiaofen, Cai, Yefeng, Chen, Endong, Zhang, Xiaohua, Wang, Ouchen, Wang, Qingxuan, Liu, Haiguang
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
Adult
AKT protein
Cell adhesion & migration
Cell growth
Cell Line, Tumor
Cell migration
Cell proliferation
Cell Proliferation - genetics
Colonies
Endocrine system
Endocrinology
Female
Humans
Male
Malignancy
Medicine
Medicine & Public Health
Metastases
Microtubule Proteins - genetics
Middle Aged
Molecular modelling
Mutation
Neoplasm Invasiveness - genetics
Oncology
Papillary thyroid cancer
Pathology
Signal Transduction - genetics
siRNA
Thyroid cancer
Thyroid Cancer, Papillary - genetics
Thyroid Cancer, Papillary - pathology
Thyroid carcinoma
Thyroid Neoplasms - genetics
Thyroid Neoplasms - pathology
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Summary:Thyroid carcinoma is the most common malignancy of the endocrine system worldwide, but its molecular mechanisms remain unclear. Some diseases are associated with TEKT4 gene. However, its role in thyroid carcinoma has yet to be fully examined. This study was designed to investigate the function of TEKT4 in papillary thyroid cancer (PTC). The effect of TEKT4 on aggressive behavior of PTC cell lines, namely, TPC1 and BCPAP, transfected with small interfering RNA was identified through cell proliferation, colony formation, migration, and invasion. Our previous study revealed that TEKT4 may be vital in PTC. In in vitro experiments, TEKT4 downregulation suppressed cell proliferation, colony formation, cell migration, and invasion. Our data also indicated that tumor-suppressing role of TEKT4 knockdown in PTC cell lines was associated with the silence of the PI3K/Akt pathway. Our study revealed that TEKT4 shows important biological implications and is worthy of further study.
ISSN:1046-3976
1559-0097
DOI:10.1007/s12022-018-9549-0