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TEKT4 Promotes Papillary Thyroid Cancer Cell Proliferation, Colony Formation, and Metastasis through Activating PI3K/Akt Pathway
Thyroid carcinoma is the most common malignancy of the endocrine system worldwide, but its molecular mechanisms remain unclear. Some diseases are associated with TEKT4 gene. However, its role in thyroid carcinoma has yet to be fully examined. This study was designed to investigate the function of TE...
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| Published in: | Endocrine pathology 2018-12, Vol.29 (4), p.310-316 |
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| Main Authors: | , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c372t-f3fdc5887e53786a883a1e26df3eccd1e3d961cf67201ea076b10609446387df3 |
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| cites | cdi_FETCH-LOGICAL-c372t-f3fdc5887e53786a883a1e26df3eccd1e3d961cf67201ea076b10609446387df3 |
| container_end_page | 316 |
| container_issue | 4 |
| container_start_page | 310 |
| container_title | Endocrine pathology |
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| creator | Zheng, Zhouci Zhou, Xiaofen Cai, Yefeng Chen, Endong Zhang, Xiaohua Wang, Ouchen Wang, Qingxuan Liu, Haiguang |
| description | Thyroid carcinoma is the most common malignancy of the endocrine system worldwide, but its molecular mechanisms remain unclear. Some diseases are associated with TEKT4 gene. However, its role in thyroid carcinoma has yet to be fully examined. This study was designed to investigate the function of TEKT4 in papillary thyroid cancer (PTC). The effect of TEKT4 on aggressive behavior of PTC cell lines, namely, TPC1 and BCPAP, transfected with small interfering RNA was identified through cell proliferation, colony formation, migration, and invasion. Our previous study revealed that TEKT4 may be vital in PTC. In in vitro experiments, TEKT4 downregulation suppressed cell proliferation, colony formation, cell migration, and invasion. Our data also indicated that tumor-suppressing role of TEKT4 knockdown in PTC cell lines was associated with the silence of the PI3K/Akt pathway. Our study revealed that TEKT4 shows important biological implications and is worthy of further study. |
| doi_str_mv | 10.1007/s12022-018-9549-0 |
| format | article |
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Some diseases are associated with TEKT4 gene. However, its role in thyroid carcinoma has yet to be fully examined. This study was designed to investigate the function of TEKT4 in papillary thyroid cancer (PTC). The effect of TEKT4 on aggressive behavior of PTC cell lines, namely, TPC1 and BCPAP, transfected with small interfering RNA was identified through cell proliferation, colony formation, migration, and invasion. Our previous study revealed that TEKT4 may be vital in PTC. In in vitro experiments, TEKT4 downregulation suppressed cell proliferation, colony formation, cell migration, and invasion. Our data also indicated that tumor-suppressing role of TEKT4 knockdown in PTC cell lines was associated with the silence of the PI3K/Akt pathway. Our study revealed that TEKT4 shows important biological implications and is worthy of further study.</description><identifier>ISSN: 1046-3976</identifier><identifier>EISSN: 1559-0097</identifier><identifier>DOI: 10.1007/s12022-018-9549-0</identifier><identifier>PMID: 30251060</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>1-Phosphatidylinositol 3-kinase ; Adult ; AKT protein ; Cell adhesion & migration ; Cell growth ; Cell Line, Tumor ; Cell migration ; Cell proliferation ; Cell Proliferation - genetics ; Colonies ; Endocrine system ; Endocrinology ; Female ; Humans ; Male ; Malignancy ; Medicine ; Medicine & Public Health ; Metastases ; Microtubule Proteins - genetics ; Middle Aged ; Molecular modelling ; Mutation ; Neoplasm Invasiveness - genetics ; Oncology ; Papillary thyroid cancer ; Pathology ; Signal Transduction - genetics ; siRNA ; Thyroid cancer ; Thyroid Cancer, Papillary - genetics ; Thyroid Cancer, Papillary - pathology ; Thyroid carcinoma ; Thyroid Neoplasms - genetics ; Thyroid Neoplasms - pathology</subject><ispartof>Endocrine pathology, 2018-12, Vol.29 (4), p.310-316</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Endocrine Pathology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-f3fdc5887e53786a883a1e26df3eccd1e3d961cf67201ea076b10609446387df3</citedby><cites>FETCH-LOGICAL-c372t-f3fdc5887e53786a883a1e26df3eccd1e3d961cf67201ea076b10609446387df3</cites><orcidid>0000-0001-9370-3685</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30251060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Zhouci</creatorcontrib><creatorcontrib>Zhou, Xiaofen</creatorcontrib><creatorcontrib>Cai, Yefeng</creatorcontrib><creatorcontrib>Chen, Endong</creatorcontrib><creatorcontrib>Zhang, Xiaohua</creatorcontrib><creatorcontrib>Wang, Ouchen</creatorcontrib><creatorcontrib>Wang, Qingxuan</creatorcontrib><creatorcontrib>Liu, Haiguang</creatorcontrib><title>TEKT4 Promotes Papillary Thyroid Cancer Cell Proliferation, Colony Formation, and Metastasis through Activating PI3K/Akt Pathway</title><title>Endocrine pathology</title><addtitle>Endocr Pathol</addtitle><addtitle>Endocr Pathol</addtitle><description>Thyroid carcinoma is the most common malignancy of the endocrine system worldwide, but its molecular mechanisms remain unclear. Some diseases are associated with TEKT4 gene. However, its role in thyroid carcinoma has yet to be fully examined. This study was designed to investigate the function of TEKT4 in papillary thyroid cancer (PTC). The effect of TEKT4 on aggressive behavior of PTC cell lines, namely, TPC1 and BCPAP, transfected with small interfering RNA was identified through cell proliferation, colony formation, migration, and invasion. Our previous study revealed that TEKT4 may be vital in PTC. In in vitro experiments, TEKT4 downregulation suppressed cell proliferation, colony formation, cell migration, and invasion. Our data also indicated that tumor-suppressing role of TEKT4 knockdown in PTC cell lines was associated with the silence of the PI3K/Akt pathway. Our study revealed that TEKT4 shows important biological implications and is worthy of further study.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>Adult</subject><subject>AKT protein</subject><subject>Cell adhesion & migration</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell migration</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - genetics</subject><subject>Colonies</subject><subject>Endocrine system</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Malignancy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Microtubule Proteins - genetics</subject><subject>Middle Aged</subject><subject>Molecular modelling</subject><subject>Mutation</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>Oncology</subject><subject>Papillary thyroid cancer</subject><subject>Pathology</subject><subject>Signal Transduction - genetics</subject><subject>siRNA</subject><subject>Thyroid cancer</subject><subject>Thyroid Cancer, Papillary - genetics</subject><subject>Thyroid Cancer, Papillary - pathology</subject><subject>Thyroid carcinoma</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid Neoplasms - pathology</subject><issn>1046-3976</issn><issn>1559-0097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kcFu1DAQhi0EoqXwAFyQJS4cCJ2xE9s5rqIWqhaxh-VsuY6zm5LEi-0U7Y1Hx9EuICEhWZqR55t_PP4JeY3wAQHkZUQGjBWAqqirsi7gCTnHqsoJ1PJpzqEUBa-lOCMvYnwAQA7AnpMzDqxCEHBOfm6ubjclXQc_-uQiXZt9PwwmHOhmdwi-b2ljJusCbdwwLNjQdy6Y1PvpPW384KcDvfZhPN2YqaWfXTIxnz7StAt-3u7oyqb-MSPTlq5v-O3l6lvKk9Luhzm8JM86M0T36hQvyNfrq03zqbj78vGmWd0VlkuWio53ra2Ukq7iUgmjFDfomGg77qxt0fG2Fmg7IRmgMyDF_bJgXZaCK5mpC_LuqLsP_vvsYtJjH21eykzOz1EzRIa1YhXL6Nt_0Ac_hym_bqGQq7JmkCk8Ujb4GIPr9D70Y_45jaAXe_TRHp3t0Ys9eul5c1Ke70fX_un47UcG2BGIuTRtXfg7-v-qvwDMM5nK</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Zheng, Zhouci</creator><creator>Zhou, Xiaofen</creator><creator>Cai, Yefeng</creator><creator>Chen, Endong</creator><creator>Zhang, Xiaohua</creator><creator>Wang, Ouchen</creator><creator>Wang, Qingxuan</creator><creator>Liu, Haiguang</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9370-3685</orcidid></search><sort><creationdate>20181201</creationdate><title>TEKT4 Promotes Papillary Thyroid Cancer Cell Proliferation, Colony Formation, and Metastasis through Activating PI3K/Akt Pathway</title><author>Zheng, Zhouci ; 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Some diseases are associated with TEKT4 gene. However, its role in thyroid carcinoma has yet to be fully examined. This study was designed to investigate the function of TEKT4 in papillary thyroid cancer (PTC). The effect of TEKT4 on aggressive behavior of PTC cell lines, namely, TPC1 and BCPAP, transfected with small interfering RNA was identified through cell proliferation, colony formation, migration, and invasion. Our previous study revealed that TEKT4 may be vital in PTC. In in vitro experiments, TEKT4 downregulation suppressed cell proliferation, colony formation, cell migration, and invasion. Our data also indicated that tumor-suppressing role of TEKT4 knockdown in PTC cell lines was associated with the silence of the PI3K/Akt pathway. 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| ispartof | Endocrine pathology, 2018-12, Vol.29 (4), p.310-316 |
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| subjects | 1-Phosphatidylinositol 3-kinase Adult AKT protein Cell adhesion & migration Cell growth Cell Line, Tumor Cell migration Cell proliferation Cell Proliferation - genetics Colonies Endocrine system Endocrinology Female Humans Male Malignancy Medicine Medicine & Public Health Metastases Microtubule Proteins - genetics Middle Aged Molecular modelling Mutation Neoplasm Invasiveness - genetics Oncology Papillary thyroid cancer Pathology Signal Transduction - genetics siRNA Thyroid cancer Thyroid Cancer, Papillary - genetics Thyroid Cancer, Papillary - pathology Thyroid carcinoma Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology |
| title | TEKT4 Promotes Papillary Thyroid Cancer Cell Proliferation, Colony Formation, and Metastasis through Activating PI3K/Akt Pathway |
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