Population‐based trends in the prenatal diagnosis of sex chromosome aneuploidy before and after non‐invasive prenatal testing

Objective To assess the impact of non‐invasive prenatal testing (NIPT) on trends in the prenatal diagnosis of sex chromosome aneuploidy (SCA) in a population with >73,000 annual births. Method Retrospective population‐based cohort study from 1986–2016 of all women undergoing prenatal diagnosis be...

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Bibliographic Details
Published in:Prenatal diagnosis 2018-12, Vol.38 (13), p.1062-1068
Main Authors: Howard‐Bath, Allanah, Poulton, Alice, Halliday, Jane, Hui, Lisa
Format: Article
Language:English
Subjects:
Aneuploidy
Births
Diagnosis
Diagnostic systems
Fetuses
Gestation
Medical diagnosis
Population (statistical)
Population studies
Prenatal development
Prenatal diagnosis
Sex
Trends
Trisomy
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Summary:Objective To assess the impact of non‐invasive prenatal testing (NIPT) on trends in the prenatal diagnosis of sex chromosome aneuploidy (SCA) in a population with >73,000 annual births. Method Retrospective population‐based cohort study from 1986–2016 of all women undergoing prenatal diagnosis before 25 weeks gestation in the Australian state of Victoria. Statistical significance was tested using the chi‐square test for trend or proportions. Results There were 2,043,345 births and 842 SCA diagnoses from 1986–2016. The percentage of prenatal diagnostic tests leading to a SCA diagnosis increased significantly from 0.95% in 2010 to 2.93% in 2016 (p 
ISSN:0197-3851
1097-0223
DOI:10.1002/pd.5363