B-type natriuretic peptide levels and benign adiposity in obese heart failure patients

Obesity is a major risk factor for the development of chronic heart failure (CHF) and does not only pose diagnostic challenges, but also has prognostic implications for these patients. Paradoxically, obese patients with CHF have a better prognosis than thinner individuals. In recent years, it has be...

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Bibliographic Details
Published in:Heart failure reviews 2019-03, Vol.24 (2), p.219-226
Main Authors: Katsi, Vasiliki, Marketou, Maria, Antonopoulos, Alexios S., Vrachatis, Dimitrios, Parthenakis, Fragkiskos, Tousoulis, Dimitris
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose Tissue - metabolism
Adiposity - physiology
Benign
Beta blockers
Body fat
Body Fat Distribution - trends
Brain natriuretic peptide
Cardiology
Fat metabolism
Heart diseases
Heart failure
Heart Failure - blood
Heart Failure - physiopathology
Humans
Hypertension - complications
Hypertension - metabolism
Hypertrophy, Left Ventricular - epidemiology
Medicine
Medicine & Public Health
Metabolic Syndrome - complications
Metabolic Syndrome - metabolism
Natriuretic Peptide, Brain - metabolism
Obesity
Obesity - complications
Obesity - epidemiology
Phenotype
Phenotypes
Prevalence
Prognosis
Risk Factors
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Summary:Obesity is a major risk factor for the development of chronic heart failure (CHF) and does not only pose diagnostic challenges, but also has prognostic implications for these patients. Paradoxically, obese patients with CHF have a better prognosis than thinner individuals. In recent years, it has been demonstrated that the adipose tissue, even in patients with HF, is not always detrimental, and that obesity may coexist with a phenotype of benign adiposity without systemic metabolic abnormalities. Experimental data have shown that natriuretic peptides (NPs), and in particular brain natriuretic peptide (BNP), play a major role in the communication of the heart with the adipose tissue. Body fat distribution and adipose tissue function show a large degree of heterogeneity among depots and may explain the complex relationship between NPs and body fat. NPs can affect both the quality and the behaviour of fatty tissue, promoting a healthy adipocyte phenotype, and can favourably affect body fat metabolism. In this article, we review the existing literature on the bidirectional effects of BNP and adipose tissue in HF and highlight the complexity of this relationship.
ISSN:1382-4147
1573-7322
DOI:10.1007/s10741-018-9739-3