Post Syrian war impact on susceptibility rates and trends in molecular characterization of Enterobacteriaceae

Describe susceptibility and molecular profiles among Enterobacteriaceae pathogens and to explore if war, among other factors, can affect antimicrobial resistance. Clinical isolates from the Study for Monitoring Antimicrobial Resistance Trends associated with urinary tract and intra-abdominal infecti...

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Bibliographic Details
Published in:Future microbiology 2018-09, Vol.13 (12), p.1419-1430
Main Authors: Hajj, Aline, Adaimé, André, Hayajneh, Wail, Abdallah, Abeer, Itani, Tarek, Hakimé, Noha, Mallah, May, Alsamarneh, Reema, Badal, Robert, Sarkis, Dolla K
Format: Article
Language:English
Subjects:
Abdomen
Anti-Bacterial Agents - pharmacology
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Armed Conflicts
Clinical isolates
Containment
Drug resistance
Drug Resistance, Bacterial
E coli
Enterobacteriaceae
Enterobacteriaceae - drug effects
Enterobacteriaceae - genetics
Enterobacteriaceae - isolation & purification
Enterobacteriaceae Infections - microbiology
Enzymes
Humans
Intraabdominal Infections - microbiology
Laboratories
Lebanon
Microbial Sensitivity Tests
Mortality
Pathogens
Quality control
Software
Syria
Trends
Urinary tract
Urinary tract diseases
Urinary tract infections
Urogenital system
War
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Summary:Describe susceptibility and molecular profiles among Enterobacteriaceae pathogens and to explore if war, among other factors, can affect antimicrobial resistance. Clinical isolates from the Study for Monitoring Antimicrobial Resistance Trends associated with urinary tract and intra-abdominal infections between 2011 and 2015 were identified in Lebanon and Jordan. Susceptibility testing and molecular characterization were performed as per standard methods. A total of 1486 Enterobacteriaceae pathogens (including unusual pathogens) were identified. Incidence rates of  extended spectrum β-lactamases were high with an overall higher prevalence of resistance in Jordan compared with Lebanon. CTX-M-15 was the most prevalent extended spectrum β-lactamases produced and OXA-48 the most reported carbapenemases subtype. Changes in healthcare system due to war could impact regional resistance patterns and which requires a continuous surveillance program and containment plan.
ISSN:1746-0913
1746-0921
DOI:10.2217/fmb-2018-0109