Impaired myocardial fatty acid metabolism detected byI-BMIPP in patients with unstable angina pectoris: Comparison with perfusion imaging byTc-sestamibi

• Published in: Annals of nuclear medicine 1995-01, Vol.9 (3), p.125-130
• Main Authors: Takeishi, Yasuchika, Sukekawa, Hiroyasu, Saito, Haruo, Nishimura, Shozo, Shibu, Takayuki, Sasaki, Yasuhiko, Tomoike, Hitonobu
• Format: Article
• Language: English
• ISSN: 0914-7187; 1864-6433
• DOI: 10.1007/BF03165038

The present study was undertaken to determine the potential diagnostic value ofI-BMIPP scintigraphy for the detection of altered myocardial fatty acid metabolism in patients with unstable angina. Both myocardial metabolic imaging withI-BMIPP and perfusion imaging withTcsestamibi were performed at rest in 28 patients with unstable angina in the pain-free state. The regional uptakes ofI-BMIPP orTc-sestamibi were scored semiquantitatively (0 = normal, 4 = no activity) and compared with the coronary arteriographic findings. Decreased uptakes ofI-BMIPP were observed in 18 patients, and 11 patients had abnormalTc-sestamibi images. Defect scores ofI-BMIPP were larger than those ofTc-sestamibi (7.8 - 2.1 vs. 5.2 + 1.9, p < 0.01). The sensitivity for the detection of patients with unstable angina was higher inI-BMIPP than inTc-sestamibi (77% vs. 45%, p < 0.01). The site of the decreasedI-BMIPP uptake corresponded to the most stenotic coronary artery lesion in all patients.