Myocardial fatty acid metabolism in diabetic mice withI-BMIPP

In patients with diabetes mellitus, the existence of diabetic cardiomyopathy was substantiated. This study was undertaken to evaluate the myocardiac fatty acid metabolism of diabetic mice (n = 21) and controls (n = 21) inI-BMIPP in fasted and unfasted states.I-BMIPP of 370 kBq was given and thirty m...

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Bibliographic Details
Published in:Annals of nuclear medicine 1998-06, Vol.12 (3), p.133-137
Main Authors: Oshima, Motoo, Higashi, Shizuka, Kikuchi, Yoshirou, Shirai, Tatsuo, Yokokawa, Tokuzou, Kaminaga, Tatsuro, Yasukochi, Hiroshi, Furui, Shigeru
Format: Article
Language:English
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Summary:In patients with diabetes mellitus, the existence of diabetic cardiomyopathy was substantiated. This study was undertaken to evaluate the myocardiac fatty acid metabolism of diabetic mice (n = 21) and controls (n = 21) inI-BMIPP in fasted and unfasted states.I-BMIPP of 370 kBq was given and thirty minutes later, animals from both groups were killed. Samples of hearts, liver and other organs were removed, weighed and then counted in a scintillation counter. The percent injected dose/g of hearts of diabetic mice was significantly reduced compared to controls in unfasted (p < 0.05) and fasted (p < 0.01) groups. These findings may reflect impaired fatty acid utilization of the hearts in diabetic mice compared to controls.
ISSN:0914-7187
1864-6433
DOI:10.1007/BF03164777