Relationship Between Anemia and the Risk of Sudden Cardiac Arrest　― A Nationwide Cohort Study in South Korea

Background: The relationship between anemia and sudden cardiac arrest (SCA) is unclear in the general population, so we assessed it in a nationwide cohort.Methods and Results: We studied 494,948 subjects (mean age, 47.8 years; 245,333 men [49.6%]) with national health check-up data from the Korean N...

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Bibliographic Details
Published in:Circulation Journal 2018/11/24, Vol.82(12), pp.2962-2969
Main Authors: Kim, In-Jung, Yang, Pil-Sung, Kim, Tae-Hoon, Uhm, Jae-Sun, Pak, Hui-Nam, Lee, Moon-Hyoung, Sung, Jung-Hoon, Joung, Boyoung
Format: Article
Language:English
Subjects:
Adult
Aged
Anemia
Anemia - mortality
Death, Sudden, Cardiac - etiology
Female
Follow-Up Studies
General population
Humans
Incidence
Male
Middle Aged
Republic of Korea - epidemiology
Risk Factors
Sex Factors
Sudden cardiac arrest
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Summary:Background: The relationship between anemia and sudden cardiac arrest (SCA) is unclear in the general population, so we assessed it in a nationwide cohort.Methods and Results: We studied 494,948 subjects (mean age, 47.8 years; 245,333 men [49.6%]) with national health check-up data from the Korean National Health Insurance Database Cohort. During a mean follow-up period of 5.4 years, SCA occurred in 616 participants (396 men, 220 women). The incidence rates of SCA increased across the 4 anemia groups in both men (0.3, 1.5, 5.3, and 4.5 per 1,000 person-years) and women (0.2, 0.5, 0.5, and 1.2 per 1,000 person-years). The SCA risk per 1-unit decrease in hemoglobin (Hb) increased by 21% and 24%, respectively, in multivariable models adjusted for cardiovascular factors, in men (95% confidence interval [CI], 13–29%; P
ISSN:1346-9843
1347-4820
1347-4820
DOI:10.1253/circj.CJ-18-0046