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The study of the serum level of IL‐4, TGF‐β, IFN‐γ, and IL‐6 in overweight patients with and without diabetes mellitus and hypertension
Background Obesity increases the risk of diabetes mellitus (DM) and hypertension. We aimed to analyze the serum levels of cytokines that have relevance to the pathologies including, interleukin‐4 (IL‐4), transforming growth factor‐β (TGF‐β), interferon‐γ (IFN‐γ), and IL‐6 cytokines of overweight men...
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Published in: | Journal of cellular biochemistry 2019-03, Vol.120 (3), p.4147-4157 |
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Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background
Obesity increases the risk of diabetes mellitus (DM) and hypertension. We aimed to analyze the serum levels of cytokines that have relevance to the pathologies including, interleukin‐4 (IL‐4), transforming growth factor‐β (TGF‐β), interferon‐γ (IFN‐γ), and IL‐6 cytokines of overweight men with DM and/or hypertension.
Methods
The study collected serum from 164 men. The sample population contained, 54 overweight men without DM or hypertension (control [CTL] group), 36 men with both DM and hypertension (DH group), 20 men with DM but no hypertension (D group), and 54 had hypertension without DM (H).
Results
The main results showed that the concentration of IFN‐γ in the DH group was significantly higher than the D, H, and CTL groups, IL‐6 in DH and D groups was significantly lower than the CTL group. The serum level of TGF‐β and IL‐4 cytokines did not show any significant differences across the four groups. Serum levels of IL‐6 were also significantly lower in untreated patients in D group than controls and in DH when compared with H groups.
Conclusion
In conclusion, it appears that the proinflammatory and anti‐inflammatory cytokines either play a significant role in the pathogenesis of hypertension and DM or serve as markers for these pathologies. Accordingly, increased serum levels of IFN‐γ may participate in the pathogenesis of hypertension in the diabetic patients and decreased IL‐6 is associated with type 2 DM.
•Obesity increases the risk of diabetes (D) and hypertension in cytokines dependent manners.
•Interferon‐γ in diabetes/hypertension (DH) patients is significantly higher than D, H, and controls (CTL). DH and D have lower interleukin‐6 than CTL. It is also lower in untreated cases in D group than CTL and in DH than H. Transforming growth factor β is higher in the treated than untreated patients in DH group.
•It seems that cytokines play a significant role in the pathogenesis of hypertension in diabetes. |
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ISSN: | 0730-2312 1097-4644 |
DOI: | 10.1002/jcb.27700 |