Tessaric acid derivatives induce G sub(2)/M cell cycle arrest in human solid tumor cell lines

A series of analogs were synthesized in a straightforward manner from naturally available sesquiterpenes ilicic acid and tessaric acid. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, HBL-100, HeLa, SW1573, T-47D and WiDr. The most potent analog ind...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2009-09, Vol.17 (17), p.6251-6256
Main Authors: Leon, Leticia G, Donadel, Osvaldo J, Tonn, Carlos E, Padron, Jose M
Format: Article
Language:English
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Summary:A series of analogs were synthesized in a straightforward manner from naturally available sesquiterpenes ilicic acid and tessaric acid. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, HBL-100, HeLa, SW1573, T-47D and WiDr. The most potent analog induced considerably growth inhibition in the range 1.9-4.5 kM. Cell cycle studies for tessaric acid derivatives indicated a prominent arrest of the cell cycle at the G sub(2)/M phase. Damage to the cells was permanent as determine by the so called 24+24 drug schedule.
ISSN:0968-0896
DOI:10.1016/j.bmc.2009.07.053