Amantadine for levodopa-induced choreic dyskinesia in compound heterozygotes for GCH1 mutations

Amantadine suppressed severe levodopa‐induced choreic dyskinesia, which developed at initiation of levodopa therapy, in two siblings manifesting dystonia with motor delay phenotype of GTP cyclohydrolase I deficiency caused by compound heterozygous GCH1 mutations. Our finding suggests a beneficial ef...

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Bibliographic Details
Published in:Movement disorders 2004-10, Vol.19 (10), p.1256-1258
Main Authors: Furukawa, Yoshiaki, Filiano, James J., Kish, Stephen J.
Format: Article
Language:English
Subjects:
amantadine
Amantadine - therapeutic use
Antiparkinson Agents - adverse effects
Antiparkinson Agents - therapeutic use
Biological and medical sciences
Child
Chorea - complications
Chorea - drug therapy
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dopamine Agents - therapeutic use
Drug toxicity and drugs side effects treatment
Dyskinesia, Drug-Induced - drug therapy
Dyskinesia, Drug-Induced - etiology
GTP Cyclohydrolase - genetics
GTP cyclohydrolase I deficiency
Heterozygote
Humans
Levodopa - adverse effects
levodopa-induced dyskinesias
Male
Medical sciences
Neurology
Parkinson Disease - drug therapy
Parkinson Disease - genetics
Pedigree
Pharmacology. Drug treatments
Phenotype
Point Mutation - genetics
Toxicity: nervous system and muscle
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Summary:Amantadine suppressed severe levodopa‐induced choreic dyskinesia, which developed at initiation of levodopa therapy, in two siblings manifesting dystonia with motor delay phenotype of GTP cyclohydrolase I deficiency caused by compound heterozygous GCH1 mutations. Our finding suggests a beneficial effect of amantadine on this type of dyskinesia frequently observed in relatively severe dopamine‐deficient metabolic disorders. © 2004 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.20194