For Whom the Cell Tolls? Intratumoral Treatment Links Innate and Adaptive Immunity

Intratumoral immunotherapy can potentially modulate the tumor microenvironment (TME) and potentiate the effects of concomitant or sequential systemic immunotherapies. Intratumoral administration of different Toll-like receptor agonists, including TLR4, can potentiate these effects through innate and...

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Bibliographic Details
Published in:Clinical cancer research 2019-02, Vol.25 (4), p.1127-1129
Main Authors: Marquez-Rodas, Ivan, Aznar, María Angela, Calles, Antonio, Melero, Ignacio
Format: Article
Language:English
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Summary:Intratumoral immunotherapy can potentially modulate the tumor microenvironment (TME) and potentiate the effects of concomitant or sequential systemic immunotherapies. Intratumoral administration of different Toll-like receptor agonists, including TLR4, can potentiate these effects through innate and adaptive immunity connection.See related article by Bhatia et al., p. 1185.
ISSN:1078-0432
1557-3265
DOI:10.1158/1078-0432.CCR-18-2690