Outcomes with newly proposed classification of acute respiratory deterioration in idiopathic pulmonary fibrosis

Respiratory-related hospitalization, in particular acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF), is common and associated with increasing mortality in patients with IPF. We aimed to evaluate the implications of a newly proposed framework of acute respiratory deterioration (ARD) and A...

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Bibliographic Details
Published in:Respiratory medicine 2018-10, Vol.143, p.147-152
Main Authors: Teramachi, Ryo, Kondoh, Yasuhiro, Kataoka, Kensuke, Taniguchi, Hiroyuki, Matsuda, Toshiaki, Kimura, Tomoki, Yokoyama, Toshiki, Yamano, Yasuhiko, Furukawa, Taiki, Sakamoto, Koji, Hashimoto, Naozumi, Hasegawa, Yoshinori
Format: Article
Language:English
Subjects:
Acute exacerbation
Acute respiratory deterioration
Alveoli
Antibiotics
Anticoagulants
Bronchus
Demographics
Demography
Fibrosis
Hospitalization
Idiopathic pulmonary fibrosis
Infections
Inflammation
Lung diseases
Mortality
Multivariate analysis
Patients
Pneumonia
Pulmonary fibrosis
Regression analysis
Statistical analysis
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Summary:Respiratory-related hospitalization, in particular acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF), is common and associated with increasing mortality in patients with IPF. We aimed to evaluate the implications of a newly proposed framework of acute respiratory deterioration (ARD) and AE-IPF in hospitalized patients. Using the data of an IPF cohort consisting of 225 consecutive patients, we retrospectively studied first hospitalizations from January 2008 to December 2017. We analysed the demographics and 90-day mortality of patients with AE-IPF and those with parenchymal cause of ARD other than AE. Among 122 patients with first hospitalization for ARD, 35 patients were diagnosed with AE-IPF, including 11 patients with triggered AE. Parenchymal cause of ARD other than AE was diagnosed in 71 patients, and extra-parenchymal cause in 16 patients. Almost all hospitalized patients (93%) underwent chest CT, and 83% of patients with AE-IPF underwent bronchoalveolar lavage. There was a significant difference in the anti-inflammatory therapy between the AE-IPF group and parenchymal cause of ARD other than AE group (p 
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2018.09.011