Spexin in the physiology of pancreatic islets—mutual interactions with insulin

Spexin is an interesting peptide, which may play an important role in the regulation of the metabolic homeostasis of an organism. Current knowledge on spexin expression, secretion, and influence on tissues and endocrine glands is very limited. We investigated spexin localization in the endocrine pan...

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Bibliographic Details
Published in:Endocrine 2019-03, Vol.63 (3), p.513-519
Main Authors: Sassek, Maciej, Kolodziejski, Pawel A., Szczepankiewicz, Dawid, Pruszynska-Oszmalek, Ewa
Format: Article
Language:English
Subjects:
Animals
Beta cells
Diabetes
Endocrine glands
Endocrinology
Gene expression
Glucose
Homeostasis
Humanities and Social Sciences
In Vitro Techniques
Insulin
Insulin - metabolism
Internal Medicine
Islets of Langerhans - metabolism
Localization
Medicine
Medicine & Public Health
multidisciplinary
Original Article
Pancreas
Peptide Hormones - metabolism
Science
Secretion
Swine
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Summary:Spexin is an interesting peptide, which may play an important role in the regulation of the metabolic homeostasis of an organism. Current knowledge on spexin expression, secretion, and influence on tissues and endocrine glands is very limited. We investigated spexin localization in the endocrine pancreas and measured its in vitro secretion from isolated pancreatic islets at various glucose concentrations, simultaneously monitoring insulin release. Also, gene expression for spexin and insulin was estimated. We found the presence of spexin inside beta cells and an increase in its release from islets after a short term and decrease after a long term following glucose administration. Finally, negative feedback loops between spexin and insulin were found, indicating the presence of multilateral relationships between glucose, insulin, and spexin inside pancreatic islets.
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-018-1766-2