A Child With Valproic Acid-Associated Carnitine Deficiency and Carnitine-Responsive Cardiac Dysfunction

Valproic acid enhances renal losses of carnitine esters and leads to decreased plasma free carnitine concentrations in many patients receiving valproic acid therapy. However, decreased serum carnitine levels are of unclear pathologic significance, and most children manifest no symptoms of carnitine...

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Bibliographic Details
Published in:Journal of child neurology 1992-10, Vol.7 (4), p.413-416
Main Authors: Bratton, Susan L., Garden, Alexander L., Bohan, Timothy P., French, James W., Clarke, William R.
Format: Article
Language:English
Subjects:
Carnitine - analysis
Carnitine - deficiency
Carnitine - metabolism
Child
Developmental Disabilities - complications
Developmental Disabilities - metabolism
Heart Diseases - complications
Heart Diseases - physiopathology
Humans
Male
Metabolic Diseases - complications
Myocardium - metabolism
Valproic Acid - adverse effects
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Summary:Valproic acid enhances renal losses of carnitine esters and leads to decreased plasma free carnitine concentrations in many patients receiving valproic acid therapy. However, decreased serum carnitine levels are of unclear pathologic significance, and most children manifest no symptoms of carnitine deficiency. We report a child with valproic acid-associated carnitine deficiency who had severe cardiac dysfunction develop that resolved with carnitine replacement therapy. (J Child Neurol 1992;7:413-416).
ISSN:0883-0738
1708-8283
DOI:10.1177/088307389200700416