Transporters in Drug Development: Scientific and Regulatory Considerations

Transporters can affect a drug's pharmacokinetics (PK) by controlling absorption, distribution, and elimination processes. They can also affect a drug's pharmacodynamics (PD) by influencing its access to the site of action. More recently, transporters have become important as drug targets...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2018-11, Vol.104 (5), p.793-796
Main Authors: Zhang, Lei, Huang, Shiew‐Mei, Reynolds, Kellie, Madabushi, Rajanikanth, Zineh, Issam
Format: Article
Language:English
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Summary:Transporters can affect a drug's pharmacokinetics (PK) by controlling absorption, distribution, and elimination processes. They can also affect a drug's pharmacodynamics (PD) by influencing its access to the site of action. More recently, transporters have become important as drug targets (e.g., urate transporter inhibitors as treatment for gout and sodium/glucose cotransporter-2 inhibitors for treating type 2 diabetes). As such, it is important to consider the role of transporters during drug development.
ISSN:0009-9236
1532-6535
DOI:10.1002/cpt.1214