Prevalence of Congenital Heart Disease at Live Birth in China

• Published in: The Journal of pediatrics 2019-01, Vol.204, p.53-58
• Main Authors: Zhao, Qu-Ming, Liu, Fang, Wu, Lin, Ma, Xiao-Jing, Niu, Conway, Huang, Guo-Ying
• Format: Article
• Language: English
• Subjects: China - epidemiology; congenital heart disease; Cross-Sectional Studies; Female; Heart Defects, Congenital - epidemiology; Humans; Infant, Newborn; Live Birth; Male; Neonatal Screening - methods; newborn screening; Prevalence; Prospective Studies
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2018.08.040

To investigate the prevalence of congenital heart disease (CHD) in China based on a large prospective multicenter screening study. A total of 122 765 consecutive infants born at 18 hospitals throughout China between August 1, 2011, and November 30, 2012, were included. Cases of CHD were identified by echocardiography, clinical assessment, and telephone follow-up. The overall prevalence of CHD was 8.98 per 1000 live births (critical, 1.46; serious, 1.47; significant, 5.00; nonsignificant, 1.07), including 7.15 in male infants and 11.11 in female infants. The most common CHD was ventricular septal defect (3.3), followed by atrial septal defect (1.7), patent ductus arteriosus (0.78), pulmonary stenosis (0.73), tetralogy of Fallot (0.47), and transposition of the great arteries (0.35). Female predominance was observed for all CHD and mild CHD (significant and nonsignificant), and male predominance was observed for the critical CHDs. The proportion of preterm newborns was substantially higher among the major CHD cases (critical and serious) compared with normal newborns. There were appreciably more low birth weight infants among the critical CHD cases compared with normal newborns. Significantly higher rates of ventricular septal defect and atrioventricular septal defect were found in infants born to mothers aged ≥35 years. Extracardiac anomalies were found in 9.3% of CHD cases. The risk of CHD was increased by approximately 3-fold when a first-degree relative had CHD. Our estimates are concordant with data from Western studies. This screening study may provide more accurate and complete information on the overall prevalence of CHD in China.