The mRNA expression of PTTG1 is a strong prognostic indicator for recurrence after hypophysectomy in dogs with corticotroph pituitary adenomas

•The mRNA expression of PTTG1 was studied in canine pituitary adenomas.•PTTG1 was overexpressed in adenoma tissue approximately 3-fold.•Dogs with high PTTG1 expression had significantly shorter disease-free intervals.•PTTG1 can be used as a clinical prognosticator in canine Cushing’s disease. Pituit...

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Bibliographic Details
Published in:The veterinary journal (1997) 2018-10, Vol.240, p.19-21
Main Authors: Vastenhout, N., van Rijn, S.J., Riemers, F.M., Tryfonidou, M.A., Meij, B.P., Penning, L.C.
Format: Article
Language:English
Subjects:
ACTH-Secreting Pituitary Adenoma - metabolism
ACTH-Secreting Pituitary Adenoma - surgery
ACTH-Secreting Pituitary Adenoma - veterinary
Animals
Biomarkers, Tumor - metabolism
Dog
Dog Diseases - metabolism
Dog Diseases - surgery
Dogs
Female
Hypophysectomy
Hypophysectomy - veterinary
Male
Neoplasm Recurrence, Local - veterinary
Pituitary adenoma
Prognosis
Quantitative RT-PCR
RNA, Messenger - metabolism
Securin - genetics
Survival time
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Summary:•The mRNA expression of PTTG1 was studied in canine pituitary adenomas.•PTTG1 was overexpressed in adenoma tissue approximately 3-fold.•Dogs with high PTTG1 expression had significantly shorter disease-free intervals.•PTTG1 can be used as a clinical prognosticator in canine Cushing’s disease. Pituitary-dependent hypercortisolism (PDH) is a common endocrinopathy in dogs, but the promotors and initiators of the tumourigenesis of corticotroph pituitary adenomas remain unknown. Based on human data, we investigated mRNA expression of pituitary tumour transforming gene 1 (PTTG1) with quantitative RT-PCR in canine corticotroph pituitary adenomas. PTTG1 was overexpressed in adenomas approximately 3-fold. A strong association was observed between PTTG1 expression and disease-free interval; dogs with high PTTG1 expression had a significantly (4 times; P=0.02) shorter disease-free interval than dogs with low PTTG1 expression. This paper shows that PTTG1 expression is a negative prognosticator in relation to disease-free interval and recurrence in dogs undergoing transsphenoidal hypophysectomy as treatment for PDH.
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2018.08.012