Secondary progressive chronic manganism associated with markedly decreased striatal D2 receptor density

We describe a patient with chronic manganism due to intoxication 40 years ago. Whereas previous reports on acute or subacute intoxication have shown no or only small reductions in striatal D2 receptor density, we found markedly decreased D2 receptor density using 18F‐methylspiperone PET in this very...

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Bibliographic Details
Published in:Movement disorders 2003-02, Vol.18 (2), p.217-219
Main Authors: Kessler, Kirn R., Wunderlich, Gilbert, Hefter, Harald, Seitz, Rüdiger J.
Format: Article
Language:English
Subjects:
18F-methylspiperone
Aged
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Chronic Disease
chronic manganism
Cognition Disorders - diagnosis
Corpus Striatum - blood supply
Corpus Striatum - metabolism
Corpus Striatum - pathology
Disease Progression
Humans
Male
Manganese Poisoning - diagnostic imaging
Manganese Poisoning - metabolism
Manganese Poisoning - pathology
Medical sciences
Metals and various inorganic compounds
multiple system atrophy
Multiple System Atrophy - metabolism
Multiple System Atrophy - pathology
Nervous system (semeiology, syndromes)
Nervous system as a whole
Neurology
Neuropsychological Tests
PET
Receptors, Dopamine D2 - metabolism
Tomography, Emission-Computed
Toxicology
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Summary:We describe a patient with chronic manganism due to intoxication 40 years ago. Whereas previous reports on acute or subacute intoxication have shown no or only small reductions in striatal D2 receptor density, we found markedly decreased D2 receptor density using 18F‐methylspiperone PET in this very late stage of chronic manganism, supporting the hypothesis that manganese intoxication may trigger a neurodegenerative disease process. © 2002 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.10325