The amyloid-β peptide and its role in Alzheimer's disease

Amyloid formation plays a central role in the cause and progression of Alzheimer's disease. The major component of this amyloid is the amyloid‐β (Aβ) peptide, which is currently the subject of intense study. This review discusses some recent studies in the area of Aβ synthesis, purification and...

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Bibliographic Details
Published in:Journal of peptide science 2001-05, Vol.7 (5), p.227-249
Main Authors: Clippingdale, Andrew B., Wade, John D., Barrow, Colin J.
Format: Article
Language:English
Subjects:
aggregation
Alzheimer Disease - metabolism
Alzheimer's disease
Amino Acid Sequence
amyloid
Amyloid beta-Peptides - chemistry
Amyloid beta-Peptides - physiology
amyloid-β peptide
Animals
Circular Dichroism
fibrilogenesis
Humans
Magnetic Resonance Spectroscopy
metal ions
Models, Biological
Models, Chemical
Molecular Sequence Data
neurotoxicity
peptide synthesis
Peptides - chemistry
Peptides - physiology
Protein Binding
Protein Isoforms
Protein Structure, Secondary
Protein Structure, Tertiary
structural analysis
therapeutic strategies
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Summary:Amyloid formation plays a central role in the cause and progression of Alzheimer's disease. The major component of this amyloid is the amyloid‐β (Aβ) peptide, which is currently the subject of intense study. This review discusses some recent studies in the area of Aβ synthesis, purification and structural analysis. Also discussed are proposed mechanisms for Aβ‐induced neurotoxicity and some recent advances in the development of Aβ‐related therapeutic strategies. Copyright © 2001 European Peptide Society and John Wiley & Sons, Ltd.
ISSN:1075-2617
1099-1387
DOI:10.1002/psc.324