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The amyloid-β peptide and its role in Alzheimer's disease
Amyloid formation plays a central role in the cause and progression of Alzheimer's disease. The major component of this amyloid is the amyloid‐β (Aβ) peptide, which is currently the subject of intense study. This review discusses some recent studies in the area of Aβ synthesis, purification and...
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| Published in: | Journal of peptide science 2001-05, Vol.7 (5), p.227-249 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c3824-500696ffb787ff1a97e22f85ab89de29767531dc102e5b574be50bc0a52b8e423 |
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| cites | cdi_FETCH-LOGICAL-c3824-500696ffb787ff1a97e22f85ab89de29767531dc102e5b574be50bc0a52b8e423 |
| container_end_page | 249 |
| container_issue | 5 |
| container_start_page | 227 |
| container_title | Journal of peptide science |
| container_volume | 7 |
| creator | Clippingdale, Andrew B. Wade, John D. Barrow, Colin J. |
| description | Amyloid formation plays a central role in the cause and progression of Alzheimer's disease. The major component of this amyloid is the amyloid‐β (Aβ) peptide, which is currently the subject of intense study. This review discusses some recent studies in the area of Aβ synthesis, purification and structural analysis. Also discussed are proposed mechanisms for Aβ‐induced neurotoxicity and some recent advances in the development of Aβ‐related therapeutic strategies. Copyright © 2001 European Peptide Society and John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/psc.324 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 1075-2617 |
| ispartof | Journal of peptide science, 2001-05, Vol.7 (5), p.227-249 |
| issn | 1075-2617 1099-1387 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_21155611 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | aggregation Alzheimer Disease - metabolism Alzheimer's disease Amino Acid Sequence amyloid Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - physiology amyloid-β peptide Animals Circular Dichroism fibrilogenesis Humans Magnetic Resonance Spectroscopy metal ions Models, Biological Models, Chemical Molecular Sequence Data neurotoxicity peptide synthesis Peptides - chemistry Peptides - physiology Protein Binding Protein Isoforms Protein Structure, Secondary Protein Structure, Tertiary structural analysis therapeutic strategies |
| title | The amyloid-β peptide and its role in Alzheimer's disease |
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