Serum endocan and circadian heart rate variability in non-dialysis stage 5 chronic kidney disease patients

• Published in: International urology and nephrology 2018-11, Vol.50 (11), p.2061-2066
• Main Authors: Bao, Yu, Wang, Yi-An, Xiao, Hua, Wang, Ying, Wu, Yan, Yan, Yue, Zhu, Zhu, Ni, Mei, Pi, Cheng-Xian, Liu, Ming-Yue, Yang, Jun-Hua, Li, Yan-Ting, Tian, Xin-Kui, Wang, Tao, Zhe, Xing-Wei
• Format: Article
• Language: English
• Subjects: Adult; Aged; Cardiovascular diseases; Circadian Rhythm - physiology; Circadian rhythms; Cross-Sectional Studies; Dialysis; Enzyme-linked immunosorbent assay; Female; Glomerular Filtration Rate; Heart rate; Heart Rate - physiology; Hemodialysis; Humans; Kidney diseases; Kidneys; Male; Medicine; Medicine & Public Health; Middle Aged; Mortality; Neoplasm Proteins - blood; Nephrology; Nephrology - Original Paper; Proteoglycans - blood; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - physiopathology; Sensitivity and Specificity; Urology
• ISSN: 0301-1623; 1573-2584
• DOI: 10.1007/s11255-018-1993-8

Background Chronic kidney disease (CKD) is very common now and is associated with high overall and cardiovascular mortality. Numerous studies have reported that elevated heart rate (HR) is a risk factor for cardiovascular mortality. We investigated the link between serum endocan and circadian heart rate variability in non-dialysis stage 5 CKD patients. Methods In a cross-sectional study, we enrolled 54 prevalent n non-dialysis stage 5 CKD patients (32 males, aged 48.2 ± 14.92 years). HR was measured with an automatic system. Serum endocan level was analyzed by ELISA. Results Night/day HR ratio was independently predicted by serum endocan level ( P