Assessment of novel core–shell Fe3O4@poly l‑DOPA nanoparticles for targeted Taxol® delivery to breast tumor in a mouse model

• Published in: Materials Science & Engineering C 2018-12, Vol.93, p.1036-1043
• Main Authors: Hashemi-Moghaddam, Hamid, Zavareh, Saeed, Gazi, Elnaz Mirsaeed, Jamili, Mahdi
• Format: Article
• Language: English
• Subjects: Breast cancer; Magnetic nanoparticles; Poly l‑DOPA; Taxol
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2018.09.005

Drug delivery systems using nanoparticles can deliver to tumor cells without affecting normal cells. In this study, a novel well dispersed magnetic nano drug was synthesized. Thus, a selective drug delivery system was designed for potential cancer treatment. A new nanocomposite, poly 3,4‑dihydroxy‑l‑phenylalanine/Fe3O4 (l‑DOPA/Fe3O4), was synthesized and used for targeted Taxol® delivery to breast tumor in inbreed Balb/c mice model with or without magnetic field. Fe and Taxol® concentrations were measured by flame atomic absorption spectrometry and high-performance liquid chromatography, respectively. Antitumor effectiveness was investigated in terms of tumor growth features. In the presence of magnetic field, Taxol® was significantly deposited in tumor tissue in Taxol-nanocomposite-treated group. In addition, the Taxol®-nanocomposite-treated group with magnetic field showed higher antitumor efficacy than the commercial Taxol and Taxol-nanocomposite without magnetic field. The magnetic nanocomposite is promising for targeted Taxol® delivery to breast tumor in a mouse model yielding high performance. •Applying of a novel polymer for drug delivery•Excellent Biocompatibility•Improve of drug bio distribution•Significant increase of drug impact•Significant decrease of drug side effects