Globus pallidus internus deep brain stimulation for dystonic conditions: A prospective audit

In the current era of functional surgery for movement disorders, deep brain stimulation (DBS) of the globus pallidus internus (GPi) is emerging as the favoured target in the treatment of patients with dystonia. The results of 25 consecutive patients with medically intractable dystonia (12 with gener...

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Bibliographic Details
Published in:Movement disorders 2003-04, Vol.18 (4), p.436-442
Main Authors: Yianni, John, Bain, Peter, Giladi, Nir, Auca, Marieta, Gregory, Ralph, Joint, Carole, Nandi, Dipankar, Stein, John, Scott, Richard, Aziz, Tipu
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Botulinum Toxins - administration & dosage
Child
Combined Modality Therapy
dystonia
Dystonia - physiopathology
Dystonia - therapy
Electric Stimulation Therapy - methods
Electrodes, Implanted
Female
Follow-Up Studies
Globus Pallidus - physiopathology
Humans
Male
Medical Audit
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Nervous system as a whole
Neurologic Examination
Neurology
pallidum
Prospective Studies
stereotactic
stimulation
Torticollis - physiopathology
Torticollis - therapy
Treatment Outcome
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Summary:In the current era of functional surgery for movement disorders, deep brain stimulation (DBS) of the globus pallidus internus (GPi) is emerging as the favoured target in the treatment of patients with dystonia. The results of 25 consecutive patients with medically intractable dystonia (12 with generalised dystonia, 7 with spasmodic torticollis, and 6 with other types of dystonia) treated with GPi stimulation are reported. Although comparisons were limited by differences in their respective neurological rating scales, chronic DBS benefited all groups, resulting in clear and progressive improvements in their condition. This study clearly demonstrates that DBS of the GPi provides amelioration of intractable dystonia. © 2002 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.10380