Quality of life: fractionated stereotactic radiotherapy versus enucleation treatment in uveal melanoma patients

Purpose To report the quality of life and visual functioning in uveal melanoma patients treated with enucleation or fractionated stereotactic radiation therapy (fSRT). Methods Uveal melanoma (UM) patients treated with fSRT (n = 65) or enucleation (n = 48) participated in this prospective study. Ques...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2018-12, Vol.96 (8), p.841-848
Main Authors: Beek, Jackelien G.M., Buitendijk, Gabrielle H.S., Timman, Reinier, Muller, Karin, Luyten, Gregorius P.M., Paridaens, Dion, Naus, Nicole C., Kiliç, Emine
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anxiety
Enucleation
Eye Enucleation
Female
Follow-Up Studies
fractionated stereotactic radiotherapy
Global health
Humans
Insomnia
Male
Melanoma
Melanoma - psychology
Melanoma - radiotherapy
Melanoma - surgery
Metastases
Metastasis
Middle Aged
Pain
Patients
Peripheral vision
Prognosis
Prospective Studies
Quality of Life
Radiation
Radiation therapy
Radiosurgery - methods
Sleep disorders
Surveys and Questionnaires
Time Factors
uveal melanoma
Uveal Neoplasms - psychology
Uveal Neoplasms - radiotherapy
Uveal Neoplasms - surgery
Visual perception
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Summary:Purpose To report the quality of life and visual functioning in uveal melanoma patients treated with enucleation or fractionated stereotactic radiation therapy (fSRT). Methods Uveal melanoma (UM) patients treated with fSRT (n = 65) or enucleation (n = 48) participated in this prospective study. Questionnaires to measure anxiety (State‐Trait Anxiety Inventory), subjective distress (Impact of Event Scale) and quality of life (EORTC‐QLQ‐C30 and National Eye Institute Visual Function Questionnaire (VFQ‐25)) were obtained before treatment and 2, 6, 12, 24, 36 and 48 months after treatment. Results Less peripheral vision was observed until 3 years (p = 0.026) posttreatment in enucleated patients compared to irradiated patients. From 2 months until 3 years posttreatment irradiated patients increase in role functioning‐score (p = 0.005), while enucleated patients decrease in score (p = 0.012). Regardless of their treatment, for all patients we measured a reduction in physical functioning (p = 0.035), insomnia (p 
ISSN:1755-375X
1755-3768
DOI:10.1111/aos.13823