One-pot synthesis of polyfunctionalized quinolines via a copper-catalyzed tandem cyclization

An efficient one-pot approach for the synthesis of polyfunctionalized quinolines was developed via a sequence of copper-catalyzed coupling reaction/propargyl-allenyl isomerization/aza-electrocyclization. Easily available starting materials, mild conditions, and a wide substrate scope make this appro...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2018-11, Vol.16 (41), p.7657-7662
Main Authors: Chen, Dianpeng, Sun, Xuejun, Shan, Yingying, You, Jinmao
Format: Article
Language:English
Subjects:
Chemical synthesis
Copper
Isomerization
Organic compounds
Quinolines
Substrates
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Summary:An efficient one-pot approach for the synthesis of polyfunctionalized quinolines was developed via a sequence of copper-catalyzed coupling reaction/propargyl-allenyl isomerization/aza-electrocyclization. Easily available starting materials, mild conditions, and a wide substrate scope make this approach potentially useful.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob02078g