Gut microbiome modulates the toxicity of hydrazine: a metabonomic study

The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and 'conventional' Sprague Dawley rats using 1H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for...

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Bibliographic Details
Published in:Molecular bioSystems 2009-01, Vol.5 (4), p.351-355
Main Authors: Swann, Jonathan, Wang, Yulan, Abecia, Leticia, Costabile, Adele, Tuohy, Kieran, Gibson, Glenn, Roberts, David, Sidaway, James, Jones, Huw, Wilson, Ian D, Nicholson, Jeremy, Holmes, Elaine
Format: Article
Language:English
Subjects:
Animals
Carcinogens - metabolism
Carcinogens - toxicity
Gastrointestinal Tract - metabolism
Gastrointestinal Tract - microbiology
Hydrazines - metabolism
Hydrazines - toxicity
Magnetic Resonance Spectroscopy
Metabolomics - methods
Metagenome
Rats
Rats, Sprague-Dawley
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Summary:The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and 'conventional' Sprague Dawley rats using 1H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for equivalent exposures indicating that bacterial presence altered the nature or extent of response to hydrazine and that the toxic response can vary markedly in the absence of a functional microbiome.
ISSN:1742-206X
1742-2051
DOI:10.1039/b811468d