Loading…
Assessment of proadrenomedullin as diagnostic or prognostic biomarker of acute appendicitis in children with acute abdominal pain
Acute appendicitis (AA) is one of the most frequent surgical pathologies in pediatrics. To investigate the utility of proadrenomedullin (pro-ADM) for the diagnosis of AA. Prospective, analytical, observational, and multicenter study conducted in 6 pediatric emergency departments. Children up to 18 y...
Saved in:
| Published in: | The American journal of emergency medicine 2019-07, Vol.37 (7), p.1289-1294 |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c384t-5e8afe9eec3a26e1ff9efa9ea74542a0f1694438ccf5c03947f24d7d8442245c3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c384t-5e8afe9eec3a26e1ff9efa9ea74542a0f1694438ccf5c03947f24d7d8442245c3 |
| container_end_page | 1294 |
| container_issue | 7 |
| container_start_page | 1289 |
| container_title | The American journal of emergency medicine |
| container_volume | 37 |
| creator | Oikonomopoulou, Niki Míguez-Navarro, Concepción Rivas-García, Arístides García Gamiz, Mercedes López-López, Rosario Oliver-Sáez, Paloma Riaño-Méndez, Bibiana Farfan-Orte, Tamara Lobato-Salinas, Zulema Rúbies-Olives, Júlia Llena-Isla, Priscila Lancho-Monreal, Encarnación María |
| description | Acute appendicitis (AA) is one of the most frequent surgical pathologies in pediatrics.
To investigate the utility of proadrenomedullin (pro-ADM) for the diagnosis of AA.
Prospective, analytical, observational, and multicenter study conducted in 6 pediatric emergency departments. Children up to 18 years of age with suspected AA were included. Clinical, epidemiological, and analytical data were collected.
We studied 285 children with an average age of 9.5 years (95% confidence interval [CI], 9.1–9.9). AA was diagnosed in 103 children (36.1%), with complications in 10 of them (9.7%). The mean concentration of pro-ADM (nmol/L) was higher in children with AA (0.51 nmol/L, SD 0.16) than in children with acute abdominal pain (AAP) of another etiology (0.44 nmol/L, SD 0.14; p |
| doi_str_mv | 10.1016/j.ajem.2018.09.038 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2116847048</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0735675718307939</els_id><sourcerecordid>2116847048</sourcerecordid><originalsourceid>FETCH-LOGICAL-c384t-5e8afe9eec3a26e1ff9efa9ea74542a0f1694438ccf5c03947f24d7d8442245c3</originalsourceid><addsrcrecordid>eNp9kU-L1TAUxYMoznP0C7iQgBs3rfnXJgU3w6COMOBG1yEvuXFS26Qm7YhLv7kpb54LF64uF37ncO85CL2kpKWE9m_H1owwt4xQ1ZKhJVw9QgfacdYoKuljdCCSd00vO3mBnpUyEkKp6MRTdMEJU5Ky4YB-X5UCpcwQV5w8XnIyLkNMM7htmkLEpmAXzLeYyhosTnlHztsxpNnk75B3qbHbCtgsC0QXbFhDwVVu78K0G-KfYb07M0eX5hDNhBcT4nP0xJupwIuHeYm-fnj_5fqmuf388dP11W1juRJr04EyHgYAyw3rgXo_gDcDGFlfYoZ42g9CcGWt7yzhg5CeCSedEoIx0Vl-id6cfOsDPzYoq55DsTBNJkLaimaU9kpIIlRFX_-DjmnL9eBKMdETJTjpKsVOlM2plAxeLznUPH5pSvRekB71XpDeC9Jk0LWgKnr1YL0da8Z_JedGKvDuBEDN4j5A1sUGiBZcyGBX7VL4n_8fjs2kHQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2246084305</pqid></control><display><type>article</type><title>Assessment of proadrenomedullin as diagnostic or prognostic biomarker of acute appendicitis in children with acute abdominal pain</title><source>ScienceDirect Journals</source><creator>Oikonomopoulou, Niki ; Míguez-Navarro, Concepción ; Rivas-García, Arístides ; García Gamiz, Mercedes ; López-López, Rosario ; Oliver-Sáez, Paloma ; Riaño-Méndez, Bibiana ; Farfan-Orte, Tamara ; Lobato-Salinas, Zulema ; Rúbies-Olives, Júlia ; Llena-Isla, Priscila ; Lancho-Monreal, Encarnación María</creator><creatorcontrib>Oikonomopoulou, Niki ; Míguez-Navarro, Concepción ; Rivas-García, Arístides ; García Gamiz, Mercedes ; López-López, Rosario ; Oliver-Sáez, Paloma ; Riaño-Méndez, Bibiana ; Farfan-Orte, Tamara ; Lobato-Salinas, Zulema ; Rúbies-Olives, Júlia ; Llena-Isla, Priscila ; Lancho-Monreal, Encarnación María ; PROADM-DOLOR ABDOMINAL of the research net of the Spanish Society of Pediatric Emergencies (RISEUP-SPERG)</creatorcontrib><description>Acute appendicitis (AA) is one of the most frequent surgical pathologies in pediatrics.
To investigate the utility of proadrenomedullin (pro-ADM) for the diagnosis of AA.
Prospective, analytical, observational, and multicenter study conducted in 6 pediatric emergency departments. Children up to 18 years of age with suspected AA were included. Clinical, epidemiological, and analytical data were collected.
We studied 285 children with an average age of 9.5 years (95% confidence interval [CI], 9.1–9.9). AA was diagnosed in 103 children (36.1%), with complications in 10 of them (9.7%). The mean concentration of pro-ADM (nmol/L) was higher in children with AA (0.51 nmol/L, SD 0.16) than in children with acute abdominal pain (AAP) of another etiology (0.44 nmol/L, SD 0.14; p < 0.001). This difference was greater in complicated cases compared with uncomplicated AA (0.64 nmol/L, SD 0.17 and 0.50 nmol/L, SD 0.15, respectively; p = 0.005). The areas under the receiver-operating characteristic curves were 0.66 (95% CI, 0.59–0.72) for pro-ADM, 0.70 (95% CI, 0.63–0.76) for C-reactive protein (CRP), 0.84 (95% CI, 0.79–0.89) for neutrophils, and 0.84 (95% CI, 0.79–0.89) for total leukocytes. The most reliable combination to rule out AA was CRP ≤1.25 mg/dL and pro-ADM ≤0.35 nmol/L with a sensitivity of 96% and a negative predictive value of 93%.
Children with AA presented higher pro-ADM values than children with AAP of other etiologies, especially in cases of complicated AA. The combination of low values of pro-ADM and CRP can help to select children with low risk of AA.</description><identifier>ISSN: 0735-6757</identifier><identifier>EISSN: 1532-8171</identifier><identifier>DOI: 10.1016/j.ajem.2018.09.038</identifier><identifier>PMID: 30287129</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Abdomen ; Abdomen, Acute - blood ; Abdominal pain ; Adrenomedullin ; Adrenomedullin - blood ; Appendicitis ; Appendicitis - blood ; Biomarkers ; Biomarkers - blood ; Blood Cell Count ; C-reactive protein ; C-Reactive Protein - analysis ; Child ; Children ; Clinical medicine ; Emergency medical care ; Epidemiology ; Etiology ; Female ; Guardians ; Hospitals ; Humans ; Laboratories ; Leukocytes (neutrophilic) ; Male ; Medical diagnosis ; Medical prognosis ; Mortality ; Neutrophils ; Pain ; Patients ; Pediatrics ; Pneumonia ; Proadrenomedullin ; Prognosis ; Prospective Studies ; Protein Precursors - blood ; Sensitivity and Specificity ; Surgeons ; Surgery</subject><ispartof>The American journal of emergency medicine, 2019-07, Vol.37 (7), p.1289-1294</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><rights>2018. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-5e8afe9eec3a26e1ff9efa9ea74542a0f1694438ccf5c03947f24d7d8442245c3</citedby><cites>FETCH-LOGICAL-c384t-5e8afe9eec3a26e1ff9efa9ea74542a0f1694438ccf5c03947f24d7d8442245c3</cites><orcidid>0000-0003-0848-8584</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30287129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oikonomopoulou, Niki</creatorcontrib><creatorcontrib>Míguez-Navarro, Concepción</creatorcontrib><creatorcontrib>Rivas-García, Arístides</creatorcontrib><creatorcontrib>García Gamiz, Mercedes</creatorcontrib><creatorcontrib>López-López, Rosario</creatorcontrib><creatorcontrib>Oliver-Sáez, Paloma</creatorcontrib><creatorcontrib>Riaño-Méndez, Bibiana</creatorcontrib><creatorcontrib>Farfan-Orte, Tamara</creatorcontrib><creatorcontrib>Lobato-Salinas, Zulema</creatorcontrib><creatorcontrib>Rúbies-Olives, Júlia</creatorcontrib><creatorcontrib>Llena-Isla, Priscila</creatorcontrib><creatorcontrib>Lancho-Monreal, Encarnación María</creatorcontrib><creatorcontrib>PROADM-DOLOR ABDOMINAL of the research net of the Spanish Society of Pediatric Emergencies (RISEUP-SPERG)</creatorcontrib><title>Assessment of proadrenomedullin as diagnostic or prognostic biomarker of acute appendicitis in children with acute abdominal pain</title><title>The American journal of emergency medicine</title><addtitle>Am J Emerg Med</addtitle><description>Acute appendicitis (AA) is one of the most frequent surgical pathologies in pediatrics.
To investigate the utility of proadrenomedullin (pro-ADM) for the diagnosis of AA.
Prospective, analytical, observational, and multicenter study conducted in 6 pediatric emergency departments. Children up to 18 years of age with suspected AA were included. Clinical, epidemiological, and analytical data were collected.
We studied 285 children with an average age of 9.5 years (95% confidence interval [CI], 9.1–9.9). AA was diagnosed in 103 children (36.1%), with complications in 10 of them (9.7%). The mean concentration of pro-ADM (nmol/L) was higher in children with AA (0.51 nmol/L, SD 0.16) than in children with acute abdominal pain (AAP) of another etiology (0.44 nmol/L, SD 0.14; p < 0.001). This difference was greater in complicated cases compared with uncomplicated AA (0.64 nmol/L, SD 0.17 and 0.50 nmol/L, SD 0.15, respectively; p = 0.005). The areas under the receiver-operating characteristic curves were 0.66 (95% CI, 0.59–0.72) for pro-ADM, 0.70 (95% CI, 0.63–0.76) for C-reactive protein (CRP), 0.84 (95% CI, 0.79–0.89) for neutrophils, and 0.84 (95% CI, 0.79–0.89) for total leukocytes. The most reliable combination to rule out AA was CRP ≤1.25 mg/dL and pro-ADM ≤0.35 nmol/L with a sensitivity of 96% and a negative predictive value of 93%.
Children with AA presented higher pro-ADM values than children with AAP of other etiologies, especially in cases of complicated AA. The combination of low values of pro-ADM and CRP can help to select children with low risk of AA.</description><subject>Abdomen</subject><subject>Abdomen, Acute - blood</subject><subject>Abdominal pain</subject><subject>Adrenomedullin</subject><subject>Adrenomedullin - blood</subject><subject>Appendicitis</subject><subject>Appendicitis - blood</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood Cell Count</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Child</subject><subject>Children</subject><subject>Clinical medicine</subject><subject>Emergency medical care</subject><subject>Epidemiology</subject><subject>Etiology</subject><subject>Female</subject><subject>Guardians</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Leukocytes (neutrophilic)</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Mortality</subject><subject>Neutrophils</subject><subject>Pain</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Pneumonia</subject><subject>Proadrenomedullin</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Protein Precursors - blood</subject><subject>Sensitivity and Specificity</subject><subject>Surgeons</subject><subject>Surgery</subject><issn>0735-6757</issn><issn>1532-8171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kU-L1TAUxYMoznP0C7iQgBs3rfnXJgU3w6COMOBG1yEvuXFS26Qm7YhLv7kpb54LF64uF37ncO85CL2kpKWE9m_H1owwt4xQ1ZKhJVw9QgfacdYoKuljdCCSd00vO3mBnpUyEkKp6MRTdMEJU5Ky4YB-X5UCpcwQV5w8XnIyLkNMM7htmkLEpmAXzLeYyhosTnlHztsxpNnk75B3qbHbCtgsC0QXbFhDwVVu78K0G-KfYb07M0eX5hDNhBcT4nP0xJupwIuHeYm-fnj_5fqmuf388dP11W1juRJr04EyHgYAyw3rgXo_gDcDGFlfYoZ42g9CcGWt7yzhg5CeCSedEoIx0Vl-id6cfOsDPzYoq55DsTBNJkLaimaU9kpIIlRFX_-DjmnL9eBKMdETJTjpKsVOlM2plAxeLznUPH5pSvRekB71XpDeC9Jk0LWgKnr1YL0da8Z_JedGKvDuBEDN4j5A1sUGiBZcyGBX7VL4n_8fjs2kHQ</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Oikonomopoulou, Niki</creator><creator>Míguez-Navarro, Concepción</creator><creator>Rivas-García, Arístides</creator><creator>García Gamiz, Mercedes</creator><creator>López-López, Rosario</creator><creator>Oliver-Sáez, Paloma</creator><creator>Riaño-Méndez, Bibiana</creator><creator>Farfan-Orte, Tamara</creator><creator>Lobato-Salinas, Zulema</creator><creator>Rúbies-Olives, Júlia</creator><creator>Llena-Isla, Priscila</creator><creator>Lancho-Monreal, Encarnación María</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0848-8584</orcidid></search><sort><creationdate>201907</creationdate><title>Assessment of proadrenomedullin as diagnostic or prognostic biomarker of acute appendicitis in children with acute abdominal pain</title><author>Oikonomopoulou, Niki ; Míguez-Navarro, Concepción ; Rivas-García, Arístides ; García Gamiz, Mercedes ; López-López, Rosario ; Oliver-Sáez, Paloma ; Riaño-Méndez, Bibiana ; Farfan-Orte, Tamara ; Lobato-Salinas, Zulema ; Rúbies-Olives, Júlia ; Llena-Isla, Priscila ; Lancho-Monreal, Encarnación María</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-5e8afe9eec3a26e1ff9efa9ea74542a0f1694438ccf5c03947f24d7d8442245c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abdomen</topic><topic>Abdomen, Acute - blood</topic><topic>Abdominal pain</topic><topic>Adrenomedullin</topic><topic>Adrenomedullin - blood</topic><topic>Appendicitis</topic><topic>Appendicitis - blood</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood Cell Count</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Child</topic><topic>Children</topic><topic>Clinical medicine</topic><topic>Emergency medical care</topic><topic>Epidemiology</topic><topic>Etiology</topic><topic>Female</topic><topic>Guardians</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Leukocytes (neutrophilic)</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical prognosis</topic><topic>Mortality</topic><topic>Neutrophils</topic><topic>Pain</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Pneumonia</topic><topic>Proadrenomedullin</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Protein Precursors - blood</topic><topic>Sensitivity and Specificity</topic><topic>Surgeons</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oikonomopoulou, Niki</creatorcontrib><creatorcontrib>Míguez-Navarro, Concepción</creatorcontrib><creatorcontrib>Rivas-García, Arístides</creatorcontrib><creatorcontrib>García Gamiz, Mercedes</creatorcontrib><creatorcontrib>López-López, Rosario</creatorcontrib><creatorcontrib>Oliver-Sáez, Paloma</creatorcontrib><creatorcontrib>Riaño-Méndez, Bibiana</creatorcontrib><creatorcontrib>Farfan-Orte, Tamara</creatorcontrib><creatorcontrib>Lobato-Salinas, Zulema</creatorcontrib><creatorcontrib>Rúbies-Olives, Júlia</creatorcontrib><creatorcontrib>Llena-Isla, Priscila</creatorcontrib><creatorcontrib>Lancho-Monreal, Encarnación María</creatorcontrib><creatorcontrib>PROADM-DOLOR ABDOMINAL of the research net of the Spanish Society of Pediatric Emergencies (RISEUP-SPERG)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest_Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oikonomopoulou, Niki</au><au>Míguez-Navarro, Concepción</au><au>Rivas-García, Arístides</au><au>García Gamiz, Mercedes</au><au>López-López, Rosario</au><au>Oliver-Sáez, Paloma</au><au>Riaño-Méndez, Bibiana</au><au>Farfan-Orte, Tamara</au><au>Lobato-Salinas, Zulema</au><au>Rúbies-Olives, Júlia</au><au>Llena-Isla, Priscila</au><au>Lancho-Monreal, Encarnación María</au><aucorp>PROADM-DOLOR ABDOMINAL of the research net of the Spanish Society of Pediatric Emergencies (RISEUP-SPERG)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of proadrenomedullin as diagnostic or prognostic biomarker of acute appendicitis in children with acute abdominal pain</atitle><jtitle>The American journal of emergency medicine</jtitle><addtitle>Am J Emerg Med</addtitle><date>2019-07</date><risdate>2019</risdate><volume>37</volume><issue>7</issue><spage>1289</spage><epage>1294</epage><pages>1289-1294</pages><issn>0735-6757</issn><eissn>1532-8171</eissn><abstract>Acute appendicitis (AA) is one of the most frequent surgical pathologies in pediatrics.
To investigate the utility of proadrenomedullin (pro-ADM) for the diagnosis of AA.
Prospective, analytical, observational, and multicenter study conducted in 6 pediatric emergency departments. Children up to 18 years of age with suspected AA were included. Clinical, epidemiological, and analytical data were collected.
We studied 285 children with an average age of 9.5 years (95% confidence interval [CI], 9.1–9.9). AA was diagnosed in 103 children (36.1%), with complications in 10 of them (9.7%). The mean concentration of pro-ADM (nmol/L) was higher in children with AA (0.51 nmol/L, SD 0.16) than in children with acute abdominal pain (AAP) of another etiology (0.44 nmol/L, SD 0.14; p < 0.001). This difference was greater in complicated cases compared with uncomplicated AA (0.64 nmol/L, SD 0.17 and 0.50 nmol/L, SD 0.15, respectively; p = 0.005). The areas under the receiver-operating characteristic curves were 0.66 (95% CI, 0.59–0.72) for pro-ADM, 0.70 (95% CI, 0.63–0.76) for C-reactive protein (CRP), 0.84 (95% CI, 0.79–0.89) for neutrophils, and 0.84 (95% CI, 0.79–0.89) for total leukocytes. The most reliable combination to rule out AA was CRP ≤1.25 mg/dL and pro-ADM ≤0.35 nmol/L with a sensitivity of 96% and a negative predictive value of 93%.
Children with AA presented higher pro-ADM values than children with AAP of other etiologies, especially in cases of complicated AA. The combination of low values of pro-ADM and CRP can help to select children with low risk of AA.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30287129</pmid><doi>10.1016/j.ajem.2018.09.038</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0848-8584</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-6757 |
| ispartof | The American journal of emergency medicine, 2019-07, Vol.37 (7), p.1289-1294 |
| issn | 0735-6757 1532-8171 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2116847048 |
| source | ScienceDirect Journals |
| subjects | Abdomen Abdomen, Acute - blood Abdominal pain Adrenomedullin Adrenomedullin - blood Appendicitis Appendicitis - blood Biomarkers Biomarkers - blood Blood Cell Count C-reactive protein C-Reactive Protein - analysis Child Children Clinical medicine Emergency medical care Epidemiology Etiology Female Guardians Hospitals Humans Laboratories Leukocytes (neutrophilic) Male Medical diagnosis Medical prognosis Mortality Neutrophils Pain Patients Pediatrics Pneumonia Proadrenomedullin Prognosis Prospective Studies Protein Precursors - blood Sensitivity and Specificity Surgeons Surgery |
| title | Assessment of proadrenomedullin as diagnostic or prognostic biomarker of acute appendicitis in children with acute abdominal pain |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T10%3A39%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessment%20of%20proadrenomedullin%20as%20diagnostic%20or%20prognostic%20biomarker%20of%20acute%20appendicitis%20in%20children%20with%20acute%20abdominal%20pain&rft.jtitle=The%20American%20journal%20of%20emergency%20medicine&rft.au=Oikonomopoulou,%20Niki&rft.aucorp=PROADM-DOLOR%20ABDOMINAL%20of%20the%20research%20net%20of%20the%20Spanish%20Society%20of%20Pediatric%20Emergencies%20(RISEUP-SPERG)&rft.date=2019-07&rft.volume=37&rft.issue=7&rft.spage=1289&rft.epage=1294&rft.pages=1289-1294&rft.issn=0735-6757&rft.eissn=1532-8171&rft_id=info:doi/10.1016/j.ajem.2018.09.038&rft_dat=%3Cproquest_cross%3E2116847048%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c384t-5e8afe9eec3a26e1ff9efa9ea74542a0f1694438ccf5c03947f24d7d8442245c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2246084305&rft_id=info:pmid/30287129&rfr_iscdi=true |