The findings of musculoskeletal ultrasonography on primary Sjögren's syndrome patients in childhood with articular manifestations and the impact of anti-cyclic citrullinated peptide antibody

• Published in: Modern rheumatology 2019-09, Vol.29 (5), p.821-828
• Main Authors: Shabana, Kosuke, Okamoto, Nami, Sugita, Yuko, Shindo, Keisuke, Murata, Takuji, Tamai, Hiroshi, Fujiwara, Kenta
• Format: Article
• Language: English
• Subjects: Adolescent; Anti-cyclic citrullinated peptide antibody; Arthritis - blood; Arthritis - diagnostic imaging; Arthritis - etiology; Autoantibodies - blood; Child; childhood; Female; Humans; Joints - diagnostic imaging; juvenile idiopathic arthritis; Male; musculoskeletal ultrasonography; Peptides, Cyclic - blood; primary Sjogren's syndrome; Rheumatoid Factor - blood; Sjogren's Syndrome - complications; Sjogren's Syndrome - diagnostic imaging; Ultrasonography - methods; Ultrasonography - standards
• ISSN: 1439-7595; 1439-7609
• DOI: 10.1080/14397595.2018.1530849

Objective: We researched the findings of musculoskeletal ultrasound sonography (MSUS) on primary Sjogren's syndrome in childhood (pSS-C) with articular manifestations. The correlation of rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (ACPA) were investigated to evaluate the usefulness of MSUS on their articular prognosis. Method: The objective patients are pSS-C cases who visited our hospital complaining joint pain and/or joint swelling and for whom MSUS was performed. Result: Eight patients included 6 female and 2 male, 5 RF-positive patients and 3 ACPA- positive patients. The mean age of onset was 11.1 ± 3.0 years (352 physical joint findings and 284 MSUS findings. The number of joints found clinical articular manifestations was 58/352 joints, and arthritis detected by MSUS was 30/284 joints). In multivariate analysis, the odds ratio of clinical articular manifestations was significant high in RF-positivity (2.9, 95%CI 1.5-6.2). The odds ratio of arthritis detected by MSUS in ACPA-positivity was significant high (3.7, 95%CI 1.5-11.6), although odds ratio in RF-positivity had no statistical significance and a similar trend was seen in odds ratios of subclinical arthritis (4.9, 95%CI 1.6-18.0). Conclusion: It was indicated that MSUS is useful for pSS-C. ACPA-positive pSS-C patients have arthritis and subclinical arthritis more frequently than ACPA-negative patients.