Dietary fatty acids augment tissue levels of n-acylethanolamines in n-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) knockout mice

N-acylethanolamines (NAEs) are lipid signaling mediators, which can be synthesized from dietary fatty acids via n-acylphosphatidylethanolamine-phospholipase D (NAPE-PLD) and in turn influence physiological outcomes; however, the roles of NAPE-PLD upon dietary fatty acid modulation are not fully unde...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of nutritional biochemistry 2018-12, Vol.62, p.134-142
Main Authors: Lin, Lin, Metherel, Adam H, Kitson, Alex P, Alashmali, Shoug M, Hopperton, Kathryn E, Trépanier, Marc-Olivier, Jones, Peter J, Bazinet, Richard P
Format: Article
Language:English
Subjects:
1, 2-Arachidonoylglycerol
Diet
Fat composition
Fatty acids
Food intake
n-Acyl-phosphatidylethanolamine phospholipase D
n-Acylethanolamines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:N-acylethanolamines (NAEs) are lipid signaling mediators, which can be synthesized from dietary fatty acids via n-acylphosphatidylethanolamine-phospholipase D (NAPE-PLD) and in turn influence physiological outcomes; however, the roles of NAPE-PLD upon dietary fatty acid modulation are not fully understood. Presently, we examine if NAPE-PLD is necessary to increase NAEs in response to dietary fatty acid manipulation. Post-weaning male wild-type (C57Bl/6), NAPE-PLD (−/+) and NAPE-PLD (−/−) mice received isocaloric fat diets containing either beef tallow, corn oil, canola oil or fish oil (10% wt/wt from fat) for 9 weeks. Brain docosahexaenoic acid (DHA) levels were higher (P
ISSN:0955-2863
1873-4847
DOI:10.1016/j.jnutbio.2018.08.015